Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders.

Aug 31, 2020

Contributor: Bader Chaarani,Kees-Jan Kan,Scott Mackey,Philip A Spechler,Alexandra Potter,Tobias Banaschewski,Sabina Millenet,Arun L W Bokde,Uli Bromberg,Christian Büchel,Anna Cattrell,Patricia J Conrod,Sylvane Desrivières,Herta Flor,Vincent Frouin,Jürgen Gallinat,Penny Gowland,Andreas Heinz,Bernd Ittermann,Jean-Luc Martinot,Frauke Nees,Tomáš Paus,Luise Poustka,Michael N Smolka,Henrik Walter,Robert Whelan,Argyris Stringaris,Stephen T Higgins,Gunter Schumann,Hugh Garavan,Robert R Althoff,

Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders.

Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. Here, we examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2024 14-year-adolescents from five European countries.
The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), oppositional defiant disorder (ODD), and generalized anxiety (GA). Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural MRI was examined using whole brain Voxel Based Morphometry analysis and functional MRI was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models (SEM) to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.
Whole brain voxel wise analysis showed that adolescent irritable mood was associated with less grey matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p<0.05). SEM models suggested that part of the observed smaller GMV is exclusively driven by irritability separate from direct relationships between GA (or ADHD, MDD, ODD) and grey matter volume.
This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.

Copyright © 2020. Published by Elsevier Inc.

Author

admin

View all posts

About The Expert

Bader Chaarani

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA. Electronic address: Bchaarani01@gmail.com.

Kees-Jan Kan

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Scott Mackey

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Philip A Spechler

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Alexandra Potter

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Tobias Banaschewski

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.

Sabina Millenet

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.

Arun L W Bokde

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Ireland.

Uli Bromberg

University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.

Christian Büchel

University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.

Anna Cattrell

Medical Research Council – Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom.

Patricia J Conrod

Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Canada; Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom.

Sylvane Desrivières

Medical Research Council – Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom.

Herta Flor

Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.

Vincent Frouin

Neurospin, Commissariat à l’Energie Atomique, CEA-Saclay Center, Paris, France.

Jürgen Gallinat

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246 Hamburg, Germany.

Penny Gowland

Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.

Andreas Heinz

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

Bernd Ittermann

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.

Jean-Luc Martinot

Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes – Sorbonne Paris Cité and Maison de Solenn, Paris, France.

Frauke Nees

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.

Tomáš Paus

Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, M6A 2E1, Canada.

Luise Poustka

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Austria.

Michael N Smolka

Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.

Henrik Walter

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

Robert Whelan

Department of Psychology, University College Dublin.

Argyris Stringaris

King’s College London Institute of Psychiatry, London, United Kingdom.

Stephen T Higgins

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Gunter Schumann

Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Canada.

Hugh Garavan

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Robert R Althoff

Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.

Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Canada.

References

PubMed