Dental practitioners must be comfortable with treating medically compromised patients, including those with cancer. In particular, dental practitioners must be aware of the comorbidities of non-Hodgkin lymphoma in order to treat patients with an appropriate standard of care. This case report describes the oral healthcare of a patient whose recurrent non-Hodgkin lymphoma created a degree of medical complexity that required a unique treatment path. As with many patients with non-Hodgkin lymphoma, the patient’s compromised systemic health ultimately contributed to the deterioration of oral health, which in turn perpetuated the deleterious systemic concerns. As a result, both intensive medical and dental interventions were required to salvage the health of the patient. Secondary to the comprehensive medical treatment for managing the patient’s cancer, there are several considerations that dentists must consider. This article explores those pretreatment and posttreatment considerations in the context of rehabilitative dentistry.