To describe the prevalence and long-term outcomes of kidney, liver, and heart transplant for children with intellectual disability.
We performed a retrospective cohort analysis of children receiving a first kidney, liver, or heart-alone transplant in the United Network for Organ Sharing dataset from 2008-2017. Recipients with definite intellectual disability were compared with those Possible/no ID. Kaplan-Meier survival estimates were calculated for graft and patient survival. Cox proportional hazard models were used to estimate the association between ID and graft and patient survival.
Over the study period, children with definite ID accounted for 594 of 6747 (9%) first pediatric kidney-alone, 318 of 4566 (7%) first pediatric liver-alone, and 324 of 3722 (9%) first pediatric heart-alone transplant recipients. ID was not significantly associated with patient or graft survival among liver and heart transplant recipients. Among kidney transplant recipients, definite ID was significantly associated with higher graft survival and lower patient survival, but absolute differences were small.
Children with ID account for 7-9% pediatric transplant recipients with comparable long-term outcomes to other pediatric recipients. These findings provide important empirical support for policies that include children with ID as transplant candidates.

Copyright © 2021. Published by Elsevier Inc.