Tegoprazan is a novel, fast- and long-acting potassium-competitive acid blocker that suppresses gastric acid secretion, which could benefit patients with non-erosive reflux disease (NERD), a type of gastroesophageal reflux disease.
To evaluate the efficacy and safety profiles of tegoprazan compared with those of a placebo in Korean patients with NERD.
In this phase 3, double-blind, placebo-controlled, multicentre study, 324 Korean patients with NERD were randomised into three treatment groups: tegoprazan 50 mg, tegoprazan 100 mg and placebo. These drugs were provided once daily for 4 weeks. The primary endpoint was the proportion of patients with complete resolution of major symptoms (both heartburn and regurgitation) for the last 7 days of the 4-week treatment period. Other outcomes related to efficacy, safety and tolerability were also evaluated.
Among all, 42.5% (45/106), 48.5% (48/99) and 24.2% (24/99) of patients showed complete resolution of major symptoms at week 4 after receiving tegoprazan 50 mg, tegoprazan 100 mg, and placebo, respectively. Both doses of tegoprazan showed superior efficacy than the placebo (P = 0.0058 and P = 0.0004, respectively). The complete resolution rates of heartburn and proportions of heartburn-free days (as other efficacy outcomes) were significantly higher in both tegoprazan groups than in the placebo group (P < 0.05 for all). No significant difference in the incidence of treatment-emergent adverse events were noted.
Tegoprazan 50 and 100 mg showed superior therapeutic efficacy compared with the placebo, as well as a favourable safety profile in patients with NERD. Registration number: ClinicalTrials.gov identifier NCT02556021.
© 2021 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.
About The Expert
Seung Han Kim
Kwang Bum Cho
Hoon Jai Chun
Sang Woo Lee
Joong Goo Kwon
Dong Ho Lee
Sang Gyun Kim
Hwoon-Yong Jung
Ji Won Kim
Joon Seong Lee
Hyojin Park
Suck Chei Choi
Sam Ryong Jee
Hyun-Soo Kim
Kwang Hyun Ko
Seun Ja Park
Yong Chan Lee
Soo Heon Park
Ah Rong Kim
Eun Ji Kim
Hyun Wook Park
Bong Tae Kim
Geun Seog Song
References
PubMed