The aim of this study was to longitudinally investigate the association between resilience and mental health in older adults and to determine the influence of physical activity on this relationship. A total of 291 older adults were included in a 2-year follow-up study. Adjusted linear regression models evaluated the association between resilience at baseline and mental health after 2 years in sufficiently and insufficiently physically active older adults. A negative correlation was found between resilience at baseline and depression, anxiety, and stress after 2 years for the overall sample. This association changed after stratifying the group. Sufficiently physically active individuals made greater use of the resilience components “Self-Sufficiency” and “Perseverance,” whereas insufficiently physically active individuals made greater use of “Meaning of Life” and “Existential Singularity.” Physical activity can influence the relationship between resilience and mental health. These results can help guide the devising of more effective interventions for this age group.

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