Glaucoma is a common cause of vision loss in corneal transplant cases and is considered a major risk factor for graft failure. Glaucoma may present before corneal transplant surgery or increased intraocular pressure may develop after keratoplasty in up to one-third of patients. Pre-existing glaucoma should be properly controlled before keratoplasty either medically or surgically. For post-keratoplasty increase of intraocular pressure; identifying the risk factors allows attentive follow up and early management. Patients undergoing anterior lamellar keratoplasty may take advantage of reduced rates of post-keratoplasty glaucoma. Glaucoma also complicates eyes with endothelial keratoplasties, mostly related to management of intraocular pressure pikes derived from anterior chamber air bubbles. Nevertheless, the severity is less, and the intraocular pressure is more easily controlled when compared to penetrating keratoplasty. Knowledge about adequate management of glaucoma either developed before or after keratoplasty may save eyes from irreversible damage to the optic nerve and increase graft survival.Copyright © 2020. Published by Elsevier Inc.