Male hypogonadism is associated with higher risk of co-morbidity and premature mortality. It is therefore of utmost importance to identify young men, who are at highest risk of testosterone deficiency and who may benefit from preventive measures. In this context, infertile men constitute a high-risk group. The extent of testosterone replacement therapy (TRT) among infertile men, defined as men who have to undergo assisted reproduction for fatherhood, is currently unknown. Therefore, we evaluated the pattern of prescription of TRT in the years following child conception among men who have fathered children with the help of intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF). By sourcing data from national population registries, hazard ratio (HR) for subsequent TRT was assessed for IVF and ICSI treated men and compared to those who conceived spontaneously with age Cox regression analysis adjusted for age, educational level and previous intake of medicines for metabolic diseases. ICSI and IVF fathers had increased incidence of newly prescribed TRT compared to fathers conceiving spontaneously (ICSI: HR=3.81, 95% CI=3.09-4.69, p<0.001; IVF: HR=1.54, 95% CI=1.15-2.05, p=0.003). After adjustment for prescription of medication for one or more components of the MetS prior to TRT the risk estimates attenuated but remained robust both for ICSI treated (HR = 3.17 (95% CI:2.56 - 3.9) and IVF treated men (HR = 1.06 (95%CI: 1.05 - 1.07). Men who have to utilise powerful techniques, such as ICSI for fathering children, may be at risk for testosterone deficiency. Routine endocrine evaluation of men seeking fertility treatment is hence warranted.
The Relationship between Obstructive Sleep Apnea Syndrome and Obesity; a New Perspective on the Pathogenesis in Terms of Organ Crosstalk.
March 2, 2020
EXPRESSION OF MONOCYTE CHEMOTACTIC PROTEIN 2 AND TUMOR NECROSIS FACTOR ALPHA IN HUMAN NORMAL ENDOMETRIUM AND ENDOMETRIOTIC TISSUES.
November 9, 2020
An Insight into the Angiogenic and Lymphatic Interplay in Pre-eclampsia Comorbid with HIV Infection.
March 23, 2020
- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
- ENDO: 2020ENDO 2020 Annual Conference has been canceled due to COVID-19. Here are highlights of emerging data that has still been released. Keep an eye out for ENDO Online 2020, which will take place from June 8 to 22.