Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.Georg Thieme Verlag KG Stuttgart · New York.
Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.
Apr 15, 2020
Contributor: Elisa d'Alessandro,Christian Becker,Wolfgang Bergmeier,Christoph Bode,Joshua H Bourne,Helena Brown,Harry R Buller,Arina J Ten Cate-Hoek,Vincent Ten Cate,Yvonne J M van Cauteren,Yam F H Cheung,Audrey Cleuren,Danielle Coenen,Harry J G M Crijns,Ilaria de Simone,Sophie C Dolleman,Christine Espinola Klein,Delia I Fernandez,Lianne Granneman,Arnoud van T Hof,Peter Henke,Yvonne M C Henskens,Jingnan Huang,Lisa K Jennings,Natalie Jooss,Mieke Karel,Danique van den Kerkhof,Frederik A Klok,Bram Kremers,Bernhard Lämmle,Avi Leader,Annika Lundstrom,Nigel Mackman,Pier M Mannucci,Zahra Maqsood,Paola E J van der Meijden,Marc van Moorsel,Luis A Moran,John Morser,Manouk van Mourik,Stefano Navarro,Raluca A I Neagoe,Renske H Olie,Pauline van Paridon,Jens Posma,Isabella Provenzale,Pieter H Reitsma,Billy Scaf,Leon Schurgers,Jaap Seelig,Agneta Siegbahn,Bob Siegerink,Oliver Soehnlein,Eva Maria Soriano,Marcin A Sowa,Henri M H Spronk,Robert F Storey,Chukiat Tantiwong,Alicia Veninga,Xueqing Wang,Steve P Watson,Jeff Weitz,Sacha S Zeerleder,Hugo Ten Cate,
