Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chemical analyses and extended photo-patch tests have not been performed in these cases.
To determine which component present in a magazine cover are responsible for a patient’s skin reaction, determine the primary sensitiser and precisely diagnose ACD and PACD PATIENT AND METHODS: After initial photopatch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatography-mass spectrometry and high-performance liquid chromatography analyses of the magazine covers and additional photopatch tests were performed.
The first photopatch test results confirmed PACD to ketoprofen and fenofibrate, and evoked PACD to the magazine covers. 4-methyl benzophenone (4-MBP) and 1-hydroxy-cyclohexyl-phenyl-ketone (1-HCPK) were found in the magazine cover. Additional photopatch tests confirmed PACD to 1-HCPK and to benzophenone, and photo-aggravated ACD to 4-MBP. The primary sensitiser was ketoprofen.
Benzophenones are present in a wide variety of products, without always being listed on the packaging. Patients previously sensitised to other ketones, such as ketoprofen, may react to benzophenones without being able to avoid contact with these molecules. New regulations may be needed for more efficient eviction advice. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.