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The following is a summary of “Objectively measured daily steps as an outcome in a clinical trial of chronic kidney disease: a systematic review,” published in the January 2024 issue of Nephrology by Huang et al.
Researchers launched a retrospective study to dissect the impact of diverse interventions on daily step counts in patients over the full spectrum of chronic kidney disease (CKD).
They systematically searched PubMed, Embase, and Web of Science (December 2022) with an update (June 2023). Inclusion criteria comprised randomized controlled studies, quasi-experimental studies, and single-arm trials evaluating interventions’ impact on objectively measured daily steps in chronic kidney disease patients. The Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I) tool assessed non-RCT bias, and the Cochrane revised tool (ROB-2) evaluated RCT bias.
The results showed 17 studies, focusing on evaluating exercise training-based interventions (n = 10), daily step goal-oriented interventions (n = 4), mHealth interventions (n = 1), different dialysis modalities (n = 1), and a “Sit Less, Interact, Move More” intervention (n = 1). These studies displayed diversity in their characteristics and assessment tools, reflecting the heterogeneity of the findings. Increasing physical activity levels remains challenging, with few studies showing significant improvements in participants’ daily step counts from baseline to endpoint.
Investigators concluded limited CKD trials explored daily steps; well-designed studies using objective measures are crucial.
Source: bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03412-x