The following is a summary of “Creola bodies and pathogenesis of childhood asthma” published in the November 2022 Issue of Respiratory by Persson, et al. 


Pijnenburg and colleagues study various factors that may have a role in the starting stages of asthma in children as part of the scope of their in-depth review. They also investigate the disease’s pathophysiology and the treatment options that are available for it. They draw attention to contradictory observations, take notice of the vast variability of the condition, and imply that phenotypic stability may be poor when utilizing standard classification techniques. 

All of these points are important. They believe that developing multidimensional and systems biology approaches will make it possible to identify well-defined groupings of children who have asthma. This belief arises from the fact that multidimensional and systems biology approaches are relatively new. They believe that this will take place at some point in the future. Their point of view expands on clinical data that are frequently ignored, specifically the relationship between the presence of clusters of epithelial cells known as Creola bodies in sputum samples taken from newborns and the eventual development of asthma in those individuals.

Creola bodies can be found in sputum samples taken from newborns. Sputum samples taken from infants often prove Creola bodies’ presence.

Source: erj.ersjournals.com/content/60/5/2201204