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Osteoporosis

Trochanteric fractures treated by internal fixation using short intramedullary nails: does the visual intraoperative estimation of the Tip-Apex Distance (TAD) concur with its digital postoperative measurement?

Jul 05, 2021

The tip-apex distance (TAD) is the only predictor for mechanical failure after internal fixation of trochanteric fractures. The main objective of our study was to assess whether the intraoperative vis...

Effects of advanced glycation end products on osteocytes mechanosensitivity.

Jul 05, 2021

Osteocytes are extremely sensitive to mechanical loading and govern bone remodeling process. Advanced glycation end products (AGEs) have the capacity to induce osteocyte apoptosis. In order to investi...

Personalized prediction of disease activity in patients with rheumatoid arthritis using an adaptive deep neural network.

Jul 01, 2021

Deep neural networks learn from former experiences on a large scale and can be used to predict future disease activity as potential clinical decision support. AdaptiveNet is a novel adaptive recurrent...

Mining the capacity of human-associated microorganisms to trigger rheumatoid arthritis-A systematic immunoinformatics analysis of T cell epitopes.

Jul 01, 2021

Autoimmune diseases, often triggered by infection, affect ~5% of the worldwide population. Rheumatoid Arthritis (RA)-a painful condition characterized by the chronic inflammation of joints-comprises u...

Liver X receptors conserve the therapeutic target potential for the treatment of Rheumatoid arthritis.

Jul 01, 2021

Rheumatoid arthritis (RA) is a chronic multi-system autoimmune disease with extremely complex pathogenesis. Significantly altered lipid paradox related to the inflammatory burden is reported in RA pat...

High patient global assessment scores in patients with rheumatoid arthritis otherwise in remission do not reflect subclinical inflammation.

Jun 28, 2021

To assess whether high patient global assessment (PGA) scores by patients with rheumatoid arthritis (RA) otherwise in remission reflect subclinical inflammation.Cross-sectional, single-center study, i...

Evaluation of postural stability in patients screened for osteoporosis: A retrospective study of 1086 cases.

Jun 28, 2021

Although the interactions between balance, falls and fracture risk have been demonstrated in various aspects, the clinical focus of fracture risk evaluation has been on bone properties, e.g., bone min...

Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association.

Jun 28, 2021

Circulating microRNAs (c-miRs) show promise as biomarkers. This systematic review explores their potential association with age-related fracture/osteoporosis (OP), osteoarthritis (OA) and sarcopenia (...

Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk: A Mendelian Randomization Study.

Jun 24, 2021

Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) an...

Sulfatase 1 and sulfatase 2 as novel regulators of macrophage antigen presentation and phagocytosis.

Jun 24, 2021

Sulfation of heparan sulfate proteoglycans (HSPGs) is critical for the binding and signaling of ligands that mediate inflammation. Extracellular 6-O-endosulfatases regulate posttranslational sulfation...

The Characteristics of Women with Subsequent Distal Radius Fracture after Initial Distal Radius Fracture.

Jun 17, 2021

The purpose of this study was to investigate the characteristics of women with subsequent distal radius fracture (DRF) and to compare bone fragility variables in women with initial and subsequent DRF....

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome.

Jun 14, 2021

Relevant reviews highlight the association between dysfunctional mitochondria and inflammation, but few studies address the contribution of mitochondria and mitochondria-endoplasmic reticulum (ER) con...

Circadian clock genes as promising therapeutic targets for autoimmune diseases.

Jun 14, 2021

Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adapt...

MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/β-catenin pathway.

Jun 14, 2021

Dysfunction in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) leads to bone loss/osteoporosis. The catenin beta interacting protein 1 (CTNNBIP1) is an inhibitor of Wnt/β...

Biochemical and immunological changes in obesity.

Jun 10, 2021

Obesity is a syndemia that promotes high expenditures for public health, and is defined by the excess of adipose tissue that is classified according to its function and according to its anatomical dis...

Differentiating the causes of adynamic bone in advanced chronic kidney disease informs osteoporosis treatment.

Jun 10, 2021

Patients with chronic kidney disease (CKD) experience an increased fracture risk due to impaired bone quality and quantity. Low bone mineral density (BMD) predicts fracture risk in all CKD stages, inc...

Cardiovascular disease prevention in individuals with underlying chronic inflammatory disease.

Jun 10, 2021

Patients with chronic inflammatory disease have an increased risk of cardiovascular disease. This article reviews the current evidence of cardiovascular prevention in three common systemic inflammator...

Intratumoral Steroid Profiling of Adrenal Cortisol-Producing Adenomas by Liquid Chromatography- Mass Spectrometry.

Jun 07, 2021

Endogenous Cushing syndrome (CS) is an endocrine disorder marked by excess cortisol production rendering patients susceptible to visceral obesity, dyslipidemia, hypertension, osteoporosis and diabetes...

Key role for hypothalamic interleukin-6 in food-motivated behavior and body weight regulation.

Jun 07, 2021

The pro-inflammatory role of interleukin-6 (IL-6) is well-characterized. Blockade of IL-6, by Tocilizumab, is used in patients with rheumatoid arthritis and those diagnosed with cytokine storm. Howeve...

Antiresorptive and anabolic medications used in the perioperative period of patients with osteoporosis undergoing spine surgery: their impact on the biology of fusion and systematic review of the literature.

Jun 03, 2021

Osteoporosis represents the most common metabolic disease of the bone, with an estimated 10% of adults aged 50 years or older affected in the United States. This patient population is at increased ris...