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Osteoporosis

Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there.

Aug 02, 2021

To determine whether osteoarthritis (OA) pain characteristics and mechanistic pathways in pre-clinical models are phenotype-specific.Male 11-week-old C57BL6 mice had unilateral medial-meniscal-destabi...

Differential relationships between parent-child DXA and pQCT bone measures: Results from the Southampton Women's Survey.

Aug 02, 2021

To investigate the associations between indices of bone health in childhood and corresponding parental measures.The Southampton Women's Survey characterised 12,583 non-pregnant women aged 20-34 year...

Influences of the IL-6 cytokine family on bone structure and function.

Aug 02, 2021

The IL-6 family of cytokines comprises a large group of cytokines that all act via the formation of a signaling complex that includes the glycoprotein 130 (gp130) receptor. Despite this, many of these...

Genetically determined selenium concentrations and risk for autoimmune diseases.

Jul 29, 2021

Observational epidemiologic studies have reported a relationship between selenium status and risk for autoimmune diseases. However, the associations are susceptible to confounding or reverse causality...

Experiential avoidance is associated with medical and mental health diagnoses in a national sample of deployed Gulf War veterans.

Jul 29, 2021

A substantial minority of deployed Gulf War veterans developed posttraumatic stress disorder (PTSD), depression, and several chronic illnesses. Although military combat and exposure to certain nuclear...

Validating the Michigan Hand Outcomes Questionnaire in patients with rheumatoid arthritis using Rasch analysis.

Jul 26, 2021

The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a mo...

Fibromyalgianess and glucocorticoid persistence among patients with rheumatoid arthritis.

Jul 26, 2021

Over 1/3 of patients with rheumatoid arthritis (RA) exhibit evidence of fibromyalgianess, which is associated with higher rates of disability and inadequate responsiveness to RA treatment. Patients wi...

Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

Jul 26, 2021

While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulde...

Use of aromatase inhibitors in patients with breast cancer is associated with deterioration of bone microarchitecture and density.

Jul 22, 2021

To evaluate changes in bone density and architecture in postmenopausal women with breast cancer (BC) and use of aromatase inhibitor (AI).Thirty-four postmenopausal women with BC, without bone metastas...

Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for Osteoarthritis.

Jul 22, 2021

Osteoarthritis (OA) is a major health problem worldwide that affects the joints and causes severe disability. It is characterized by pain and low-grade inflammation. However, the exact pathogenesis re...

Different cutoff points to diagnose low muscle mass and prediction of osteoporosis in postmenopausal women.

Jul 22, 2021

This study aimed to verify which of the different cutoff points of low muscle mass (LMM) based on appendicular lean mass (ALM) is associated with osteoporosis in postmenopausal women (PMW).Cross-secti...

Unveiling the genetic variation of severe continuous/mixed-type ossification of the posterior longitudinal ligament by whole-exome sequencing and bioinformatic analysis.

Jul 19, 2021

Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine is known as a rare, complex genetic disease, its complexity being partly because OPLL is diagnosed by radiological find...

Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats.

Jul 19, 2021

Activation of modeling-based bone formation (MBF - bone formation without prior activation of bone resorption), has been identified as an important mechanism by which anabolic agents, such as intermit...

Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results.

Jul 19, 2021

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease, affecting almost 1% of the world population. It is a long-lasting autoimmune disease, which mainly affects the joints causi...

Automated Detection of Patellofemoral Osteoarthritis from Knee Lateral View Radiographs Using Deep Learning: Data from the Multicenter Osteoarthritis Study (MOST).

Jul 12, 2021

To assess the ability of imaging-based deep learning to detect radiographic patellofemoral osteoarthritis (PFOA) from knee lateral view radiographs.Knee lateral view radiographs were extracted from Th...

Microscale compressive behavior of hydrated lamellar bone at high strain rates.

Jul 12, 2021

The increased risk of fracture in the elderly associated with metabolic conditions like osteoporosis poses a significant strain on health care systems worldwide. Due to bone's hierarchical nature, it ...

Professional cyclists have lower levels of bone markers than amateurs. Is there a risk of osteoporosis in cyclist?

Jul 12, 2021

Currently, there are no studies that compares bone condition markers between professional (PRO) and amateur (AMA) cyclists. Amateur cyclists are the ones who practice this sport the most. Therefore, t...

Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis.

Jul 08, 2021

Rheumatoid arthritis (RA) is a common inflammatory form of arthritis leading to the progressive bone and joint destruction. Many factors are closely involved in the pathology of RA, in particular bone...

miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt/β-catenin axis.

Jul 08, 2021

Emerging evidence proves that exosomes contain specific microRNAs(miRNAs) contribute to osteogenic differentiation of bone marrow stem cells (BMSCs). However, the role and mechanism of bone marrow ste...

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation.

Jul 05, 2021

Anti-resorptive drugs are widely used for the treatment of osteoporosis, but excessive inhibition of osteoclastogenesis can suppress bone turnover and cause the deterioration of bone quality. Sialic a...