The molecular mechanisms underlying the degeneration and neuronal death associated with Parkinson’s disease (PD) are not clearly understood. Several pathways and models have been explored in an overwhelming number of...
The central nervous system (CNS) is a vital part of the human nervous system, and the incidence of CNS disease is increasing year by year, which has become a major public health problem and a prominent social problem. At...
Inducing neural stem cells to differentiate and replace degenerated functional neurons represents the most promising approach for neural degenerative diseases including Parkinson’s disease, Alzheimer’s disease, etc....
Complement pathway over-activation has been implicated in a variety of neurological diseases. However, the signaling pathways governing astrocytic complement activation in Parkinson’s disease (PD) are poorly understood....
Parkinson’s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Dopamine precursor L-dopa is used as the first-line treatment for PD. Evidence suggests...
Amyotrophic lateral sclerosis (ALS) is associated with a range of clinical phenotypes and shows progressive degeneration of upper and/or lower motor neurons, and pTDP-43 inclusions in motor and non-motor pathways. Parkinsonian...
Bradykinesia is one of the cardinal motor symptoms of Parkinson’s disease. However, clinical and experimental studies indicate that bradykinesia may also be observed in various neurological diseases not primarily...
Resting-state functional magnetic resonance imaging (Rs-fMRI) can be used to investigate the alteration of resting-state brain networks (RSNs) in patients with Parkinson’s disease (PD) when compared with healthy controls...
Purpose Studies have reported that clear speech has the potential to influence suprasegmental and segmental aspects of speech, in both healthy and dysarthric speakers. While the impact of clear speech has been studied on the...
To demonstrate that continuous subcutaneous infusion of a soluble levodopa (LD)/carbidopa (CD) phosphate prodrug combination effectively delivers stable LD exposure via a minimally invasive and convenient mode and has the...
Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone marrow-derived mesenchymal stem cells can be used as an immunomodulatory therapy.The objective of this study was to prove the safety and tolerability of...
Parkinson’s disease is a progressive neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Neuroinflammation, another hallmark of the disease, is thought to play an...
