Parkinson's Disease
May 23, 2022
Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy with neurodegeneration typically observed in the superior cerebellar peduncle (SCP) and dentatorubrothalamic tracts (DRTT). However, it is ...
May 23, 2022
Freezing of gait (FOG) is a common and debilitating gait impairment in Parkinson's disease. Further insight into this phenomenon is hampered by the difficulty to objectively assess FOG. To meet this c...
May 09, 2022
Living in greener areas is associated with slower cognitive decline and reduced dementia risk among older adults, but the evidence with neurodegenerative disease mortality is scarce. We studied the as...
Apr 25, 2022
Although several studies have reported positive effects of mind-body exercises on symptom management and health-related quality of life (HRQOL) of people living with Parkinson's disease (PD), it is no...
Apr 18, 2022
The conditionally essential amino acid arginine and its metabolic products play an important role in different biological processes, such as metabolic regulation of the immune response, including macr...
Apr 11, 2022
Parkinson's disease is characterised by the deposition of α-synuclein, which leads to synaptic dysfunction, the loss of neuronal connections and ultimately progressive neurodegeneration. Despite exte...
Apr 11, 2022
Multiple system atrophy (MSA) and Parkinson's disease (PD) belong to alpha-synucleinopathy, but they have very different clinical courses and prognoses. An imaging biomarker that can differentiate bet...
Mar 21, 2022
Decreased level of neurotrophic factor brain-derived neurotrophic factor (BDNF) has been supposed to participate in the pathoetiology of Parkinson's disease (PD). However, the underlying mechanisms of...
Mar 14, 2022
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases in the elderly. Recently, some variants of AD-causal genes (APP, PSEN1, PSEN2) have been reported i...
Mar 07, 2022
Parkinson's disease (PD) causes difficulty with maintaining the speed, size, and vigor of movements, especially when they are internally generated. We previously proposed that the insula is important ...
Feb 28, 2022
Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria p...
Feb 28, 2022
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive loss of striatal dopaminergic n...
Feb 21, 2022
CD44 is a transmembrane protein that transduces extracellular stimuli to immune response. Neuroinflammation is a causative factor in neurodegenerative diseases, such as Parkinson's disease (PD). Owing...
Feb 21, 2022
The dopamine D receptor (DR) is highly expressed in the limbic regions of the brain and closely related to a variety of neurological disorders including Parkinson's disease, schizophrenia and drug-see...
Feb 14, 2022
Subthalamic nucleus (STN) and globus pallidus interna (GPI) are the two most common sites for deep brain stimulation (DBS) in people with Parkinson's disease (PWP). Voice impairments are a common symp...
Jan 31, 2022
A motor speech disorder or dysarthria commonly arises in patients with Parkinson's disease (PD). The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor speech and the potential ...
Jan 14, 2022
To promote therapeutic treatment trials in Parkinson's disease (PD), reliable and precise imaging biomarkers of dopaminergic cell neurodegeneration are required. Neurodegeneration in the substantia ni...
Jan 14, 2022
The striatal hypercholinergic condition in Parkinson's disease (PD) and levodopa-induced dyskinesia are both caused by increased striatal cholinergic interneuron activity. Dyskinesia and motor fluctua...
Jan 14, 2022
Parkinson's disease (PD) affects the basal ganglia system, which causes movement dysfunction. Despite its crucial role in integrating basal ganglia calculations with motor function, the primary motor ...
Jan 14, 2022
Sleep disturbances are one of the most prevalent nonmotor symptoms of Parkinson's disease (PD). They can appear in the early stages of the disease and worsen as the disease progresses. Sleep disruptio...
