Interdisciplinary Home Visits for Homebound Patients With Parkinson’s Disease Maintain QOL
“In recent years, we have gained a much better understanding of the breadth and severity of both...
Parkinson’s Disease
Differential coulometry based on dual screen-printed strips for high accuracy levodopa determination towards Parkinson’s disease management.
As a vital therapeutic agent for Parkinson’s disease, dosage control of levodopa has always been a major obstacle in ensuring efficacy and curbing side effects. Simple and fast electrochemical detection methods are the...
Penetrance of Glucocerebrosidase (GBA) Mutations in Parkinson’s Disease: a Kin Cohort Study.
Homozygous glucocerebrosidase mutations cause Gaucher disease, whereas heterozygous mutations are the most important genetic risk factor for Parkinson’s disease (PD). The penetrance of heterozygous glucocerebrosidase...
Identification of CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson’s disease.
Neuroinflammation is known to be involved in the pathogenesis of Parkinson’s disease (PD). Abnormal activation of microglia plays a key role in this pathological process. CD200R1 is a membrane glycoprotein that is...
Potential sources of interference with the highly sensitive detection and quantification of alpha-Synuclein seeds by qRT-QuIC.
Parkinson’s Disease (PD) is a progressive neurodegenerative disease which is histologically characterized by loss of dopaminergic neurons in the substantia nigra and deposition of aggregated alpha-Synuclein (aSyn) in the...
Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of Levodopa.
Levodopa-carbidopa intestinal gel (LCIG) provides continuous levodopa administration and clinical benefits to patients with advanced Parkinson’s disease (PD). This report evaluates long-term safety and efficacy of...
Iron-mediated interaction of alpha synuclein with lipid raft model membranes.
The aberrant misfolding and aggregation of alpha synuclein (αS) into toxic oligomeric species is one of the key features associated with the pathogenesis of Parkinson’s disease (PD). It involves different biochemical and...
Yeast tripartite biosensors sensitive to protein stability and aggregation propensity.
In contrast to the myriad approaches available to study protein misfolding and aggregation in vitro, relatively few tools are available for the study of these processes in the cellular context. This is in part due to the...
Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice.
Mercury sulfides (HgS) are frequently included in Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but the ethnopharmacology remains elusive. The present study examined the protective effects...
Identifying Delirium in Parkinson’s Disease
People with Parkinson’s disease (PD) may be at increased risk of delirium and associated adverse outcomes. Delirium is an acute neuropsychiatric syndrome defined by confusion and inattention and is common in older adults....
Sex-dependent association of urate on the patterns of striatal dopamine depletion in Parkinson’s disease.
To investigate the relationship between the serum urate (UA) levels and patterns of striatal dopamine depletion in patients with de novo Parkinson’s disease (PD).We enrolled 167 de novo PD patients who underwent...
Physical therapy for freezing of gait and gait impairments in Parkinson’s disease: a systematic review.
Freezing of gait (FOG) is a major cause of falls and disability in Parkinson disease (PD). As FOG only partially improves in response to dopaminergic medication, physical therapy is an important element of its management. The...
