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Parkinson's Disease

Diffusion tractography of superior cerebellar peduncle and dentatorubrothalamic tracts in two autopsy confirmed progressive supranuclear palsy variants: Richardson syndrome and the speech-language variant.

May 23, 2022

Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy with neurodegeneration typically observed in the superior cerebellar peduncle (SCP) and dentatorubrothalamic tracts (DRTT). However, it is ...

Automated freezing of gait assessment with marker-based motion capture and multi-stage spatial-temporal graph convolutional neural networks.

May 23, 2022

Freezing of gait (FOG) is a common and debilitating gait impairment in Parkinson's disease. Further insight into this phenomenon is hampered by the difficulty to objectively assess FOG. To meet this c...

Long-term exposure to residential greenness and neurodegenerative disease mortality among older adults: a 13-year follow-up cohort study.

May 09, 2022

Living in greener areas is associated with slower cognitive decline and reduced dementia risk among older adults, but the evidence with neurodegenerative disease mortality is scarce. We studied the as...

Effects of Mindfulness Yoga Versus Conventional Physical Exercises on Symptom Experiences and Health-related Quality of Life in People with Parkinson's Disease: The Potential Mediating Roles of Anxiety and Depression.

Apr 25, 2022

Although several studies have reported positive effects of mind-body exercises on symptom management and health-related quality of life (HRQOL) of people living with Parkinson's disease (PD), it is no...

Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices.

Apr 18, 2022

The conditionally essential amino acid arginine and its metabolic products play an important role in different biological processes, such as metabolic regulation of the immune response, including macr...

Alpha-SYNUCLEINOPATHY reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.

Apr 11, 2022

Parkinson's disease is characterised by the deposition of α-synuclein, which leads to synaptic dysfunction, the loss of neuronal connections and ultimately progressive neurodegeneration. Despite exte...

Advanced brain aging in multiple system atrophy compared to Parkinson's disease.

Apr 11, 2022

Multiple system atrophy (MSA) and Parkinson's disease (PD) belong to alpha-synucleinopathy, but they have very different clinical courses and prognoses. An imaging biomarker that can differentiate bet...

Expression of BDNF-Associated lncRNAs in Parkinson's disease.

Mar 21, 2022

Decreased level of neurotrophic factor brain-derived neurotrophic factor (BDNF) has been supposed to participate in the pathoetiology of Parkinson's disease (PD). However, the underlying mechanisms of...

Evaluation of common and rare variants of Alzheimer's disease-causal genes in Parkinson's disease.

Mar 14, 2022

Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases in the elderly. Recently, some variants of AD-causal genes (APP, PSEN1, PSEN2) have been reported i...

Neurofeedback-guided kinesthetic motor imagery training in Parkinson's disease: Randomized trial.

Mar 07, 2022

Parkinson's disease (PD) causes difficulty with maintaining the speed, size, and vigor of movements, especially when they are internally generated. We previously proposed that the insula is important ...

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function.

Feb 28, 2022

Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria p...

Fighting Parkinson's disease: the return of the mitochondria.

Feb 28, 2022

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive loss of striatal dopaminergic n...

CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson's disease.

Feb 21, 2022

CD44 is a transmembrane protein that transduces extracellular stimuli to immune response. Neuroinflammation is a causative factor in neurodegenerative diseases, such as Parkinson's disease (PD). Owing...

Synthesis and biological evaluation of F-labelled dopamine D receptor selective ligands.

Feb 21, 2022

The dopamine D receptor (DR) is highly expressed in the limbic regions of the brain and closely related to a variety of neurological disorders including Parkinson's disease, schizophrenia and drug-see...

Voice handicap Index in Parkinson's patients: Subthalamic versus globus pallidus deep brain stimulation.

Feb 14, 2022

Subthalamic nucleus (STN) and globus pallidus interna (GPI) are the two most common sites for deep brain stimulation (DBS) in people with Parkinson's disease (PWP). Voice impairments are a common symp...

Motor speech effects in subthalamic deep brain stimulation for Parkinson's disease.

Jan 31, 2022

A motor speech disorder or dysarthria commonly arises in patients with Parkinson's disease (PD). The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor speech and the potential ...

Neuromelanin MRI Signal Changes Over Time in Parkinson's Disease

Jan 14, 2022

To promote therapeutic treatment trials in Parkinson's disease (PD), reliable and precise imaging biomarkers of dopaminergic cell neurodegeneration are required. Neurodegeneration in the substantia ni...

Striatal Cholinergic Interneuron Burst-Pause Activity Caused by Levodopa in Parkinsonian Mice

Jan 14, 2022

The striatal hypercholinergic condition in Parkinson's disease (PD) and levodopa-induced dyskinesia are both caused by increased striatal cholinergic interneuron activity. Dyskinesia and motor fluctua...

A Mouse Model of Parkinson's Disease Shows Intrinsic Disruption of the M1 Cortical Network

Jan 14, 2022

Parkinson's disease (PD) affects the basal ganglia system, which causes movement dysfunction. Despite its crucial role in integrating basal ganglia calculations with motor function, the primary motor ...

The Sleep Neurophysiology in Parkinson's Disease

Jan 14, 2022

Sleep disturbances are one of the most prevalent nonmotor symptoms of Parkinson's disease (PD). They can appear in the early stages of the disease and worsen as the disease progresses. Sleep disruptio...