While the concept of prodromal Parkinson’s disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connectivity of the putamina in a...
Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson’s disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their...
Recent work has revealed that spontaneous release plays critical roles in the central nervous system, but how it is regulated remains elusive. Here we report that synaptotagmin-11 (Syt11), a Ca -independent Syt isoform...
People with Parkinson’s disease (PD) have increased visual dependency for balance and suspected vestibular dysfunction. Immersive virtual reality (VR) allows graded manipulation of visual sensory inputs during balance...
MRgFUS has just been made available for the 1.7 million Parkinson’s disease patients in China. Despite its non-invasive and rapid therapeutic advantages for involuntary tremor, some concerns have emerged about outcomes...
Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related to pathophysiological changes in patients with...
Mobility is severely impacted in patients with Parkinson’s disease (PD), who often experience involuntary stopping from the freezing of gait (FOG). Understanding the neurophysiological difference between “voluntary...
The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) is a renowned cognitive test battery, which has been extended in its German version to the CERAD-Plus including tests of executive functions and...
Parkinson’s disease (PD) is a chronic neurodegenerative disease. Recently, neuroinflammation driven by CD4 T cells has been involved in PD pathophysiology. Human and murine lymphocytes express all the five subtypes of...
As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Given the engagement of multiple dysregulated...
This review captures recent advances in biological and translational research on stem cells. In particular, we discuss new discoveries and concepts regarding stem cell treatment of aging-related disorders. A myriad of stem cell...
Quality of life (QoL) in Parkinson’s disease (PD) depends on multiple factors. Due to PD treatment and accompanying, age-related or independent comorbidities, pill burden is often high. The relation of QoL and...
