PubMed

eLife 2018 07 137() doi 10.7554/eLife.37754 Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These...

PLoS biology 2018 07 1616(7) e2005840 doi 10.1371/journal.pbio.2005840 Abstract Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental...

Cell reports 24(3) 630-641 pii 10.1016/j.celrep.2018.06.066 Abstract The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA...

Cell 174(2) 497 pii 10.1016/j.cell.2018.06.051 Abstract

Nature communications 2018 07 139(1) 2724 doi 10.1038/s41467-018-05072-0 Abstract Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here,...

Genome biology 2018 07 1219(1) 88 doi 10.1186/s13059-018-1464-7 Abstract BACKGROUND DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases...

Molecular cell 2018 06 2871(1) 56-72.e4 pii 10.1016/j.molcel.2018.06.003 Abstract Chromatin remodeling complexes play essential roles in metazoan development through widespread control of gene expression, but the precise...

American journal of public health 2015 04 23105(6) 1120-7 doi 10.2105/AJPH.2014.302313 Abstract OBJECTIVES We estimated the prevalence of any drinking and binge drinking from 2002 to 2012 and heavy drinking from 2005 to 2012 in...

Evidence-based complementary and alternative medicine : eCAM 2018 06 072018() 9521086 doi 10.1155/2018/9521086 Abstract Showering is the most common form of bathing worldwide. Whole-body immersion bathing in warm water (~40°C)...

Cell 173(2) 278-280 doi 10.1016/j.cell.2018.03.047 Abstract

Tropical medicine & international health : TM & IH 2011 10 0417(1) 135-8 doi 10.1111/j.1365-3156.2011.02885.x Abstract OBJECTIVE Internal use of ‘camphor’ is a potential public health concern in Accra. We...

Obesity (Silver Spring, Md.) 2011 06 1620(2) 421-7 doi 10.1038/oby.2011.171 Abstract The objective of this study was to examine whether lifestyle factors were associated with 5-year change in abdominal fat measured by computed...

The New England journal of medicine 379(7) 633-644 doi 10.1056/NEJMoa1800256 Abstract BACKGROUND Patients with diabetes are at higher risk for death and cardiovascular outcomes than the general population. We investigated...

The New England journal of medicine 379(7) 623-632 doi 10.1056/NEJMoa1803626 Abstract BACKGROUND Whether weight gain after smoking cessation attenuates the health benefits of quitting is unclear. METHODS In three cohort studies...

The New England journal of medicine 379(7) 645-654 doi 10.1056/NEJMoa1711460 Abstract BACKGROUND Ibalizumab, a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive...

Blood 2018 07 06132(7) 707-716 doi 10.1182/blood-2018-03-837153 Abstract The need to accurately identify cancer outpatients at high risk of thrombotic complications is still unmet. In a prospective, multicenter cohort study...

Science (New York, N.Y.) 2018 07 05361(6403) 704-709 doi 10.1126/science.aat1022 Abstract The binding of DNA to cyclic GMP-AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP), which...

Nature 2018 07 18559(7715) 637-641 doi 10.1038/s41586-018-0350-5 Abstract Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening...

Blood 2018 07 18() pii 10.1182/blood-2017-12-823393 Abstract

Nature cell biology 2018 07 1820(8) 954-965 doi 10.1038/s41556-018-0140-1 Abstract BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP)...