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Brain Cancer Oncology

T-Cell based therapies for overcoming neuroanatomical and immunosuppressive challenges within the glioma microenvironment.

Mar 19, 2020

Glioblastoma remains as the most common and aggressive primary adult brain tumor to date. Within the last decade, cancer immunotherapy surfaced as a broadly successful therapeutic approach for a varie...

Dissociation of Pubertal Development Abnormality and Gonadal Dysfunction in Childhood Cancer Survivors.

Mar 19, 2020

To determine the relationship between pubertal development and postpubertal gonadal function in childhood cancer survivors. Childhood cancer survivors (≥10 years of age) who received follow-up car...

[A Case of Primary Central Nervous System Lymphoma that Developed during the Treatment of Castration-Resistant Prostate Cancer].

Mar 13, 2020

A 64-year-old man was diagnosed with metastatic prostate cancer (cT3bN0M1b) and treated with combined androgen blockade. After two years and three months, he developed castration-resistant prostate ca...

Brain MR Image Classification for Glioma Tumor detection using Deep Convolutional Neural Network Features.

Mar 13, 2020

Detection of brain tumor is a complicated task which requires specialized skills and interpretation techniques. Accurate brain tumor classification and segmentation from MR images provide an essential...

DENSE-INception U-net for medical image segmentation.

Mar 13, 2020

Convolutional neural networks (CNNs) play an important role in the field of medical image segmentation. Among many kinds of CNNs, the U-net architecture is one of the most famous fully convolutional n...

Corrigendum to "Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization".

Mar 13, 2020

Fluorescence image guided surgical resection (FIGR) of high grade gliomas (HGGs) takes advantage of the accumulation of the tracer protoporphyrin IX (PpIX) in glioma cells following administration of ...

Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child.

Mar 12, 2020

Angiosarcoma is a rare malignant tumor with an aggressive course and poor prognosis. It is typically seen in adults but very rarely seen in children. Angiosarcoma of the skull with brain metastasis is...

Time to diagnosis and clinical characteristics in pediatric brain tumor patients.

Mar 12, 2020

We aimed to identify factors that affect the time to diagnosis in pediatric brain tumors and investigate the effect of time to diagnosis on clinical outcome.A retrospective study of children with brai...

Image Guidance in Cranial Neurosurgery: How a Six-Ton Magnet and Fluorescent Colors Make Brain Tumor Surgery Better.

Mar 12, 2020

Maximal safe resection can improve patient outcomes for a variety of brain tumor types including low- and high-grade gliomas, pituitary adenomas, and other pathologies. Numerous intraoperative adjunct...

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells PI3K/Akt/NF-κB Signaling Pathway.

Mar 12, 2020

Glioma is the most common type of malignant brain tumor. Due to its highly aggressive and metastatic features, glioma is associated with poor prognosis and a lack of effective treatments. Eriodictyol,...

Organic Spherical Nucleic Acids Facilitate NIR-II Emitting Dye to Cross Blood-Brain Barrier.

Mar 12, 2020

DNA nanotechnology plays an increasingly important role in the biomedical field; however, its application in the design of organic nanomaterials has still been underexplored. Herein, we innovatively e...

Antiproliferative evaluation of some 2-(2-Styrylcyclopent-3-enyl) benzo[d]thiazoles: DFT and molecular docking study.

Mar 09, 2020

The 2-(2-styrylcyclopent-3-enyl)benzo-[ d ]thiazoles (5a-m) were synthesized from the reaction of 7-styrylbicyclo[3.2.0]hept-2-en-6-ones (3a-m) with 2-aminobenzenethiol (4) . The antiproliferative act...

The Current Status of Immune Checkpoint Inhibitors in Neuro-Oncology: A Systematic Review.

Mar 09, 2020

The introduction of immune checkpoint inhibitors (ICI), as a novel treatment modality, has transformed the field of oncology with unprecedented successes. However, the efficacy of ICI for patients wit...

Quantifying the Financial Savings of Motion Correction in Brain MRI: A Model-Based Estimate of the Costs Arising From Patient Head Motion and Potential Savings From Implementation of Motion Correction.

Mar 09, 2020

Patient head motion is a major concern in clinical brain MRI, as it reduces the diagnostic image quality and may increase examination time and cost.To investigate the prevalence of MR images with sign...

Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model.

Mar 09, 2020

Biological tissues contain micrometer-scale gaps and pores, including those found within extracellular matrix fiber networks, between tightly packed cells, and between blood vessels or nerve bundles a...

Adult H3K27M-mutant diffuse midline glioma with gliomatosis cerebri growth pattern: Case report and review of the literature.

Mar 09, 2020

H3K27M-mutant diffuse midline glioma is a recently classified unique entity predominantly affecting pediatric patients and rarely adults. The clinicopathologic features in adults remain poorly charact...

PET imaging of medulloblastoma with an F-labeled tryptophan analogue in a transgenic mouse model.

Mar 05, 2020

In vivo positron emission tomography (PET) imaging is a key modality to evaluate disease status of brain tumors. In recent years, tremendous efforts have been made in developing PET imaging methods fo...

Efficacy of a topical gelatin-thrombin hemostatic matrix, FLOSEAL, in intracranial tumor resection.

Mar 05, 2020

Hemostasis plays an important role in safe brain tumor resection and also reduces the risk for surgical complications. This study aimed to evaluate the efficacy of FLOSEAL, a topical hemostatic agent ...

Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.

Mar 05, 2020

We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), ...

Organ donation from brain-dead pediatric donors in Korea: A 5-year data analysis (2013-2017).

Mar 05, 2020

In Korea, 2-4% of brain-dead organ donations are from donors ...