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Brain Cancer Oncology

Hybridization of tumor homing and mitochondria-targeting peptide domains to design novel dual-imaging self-assembled peptide nanoparticles for theranostic applications.

Sep 20, 2021

A novel hybridized dual-targeting peptide-based nanoprobe was successfully designed by using the cyclic heptapeptide. This peptide has Arg-Gly-Asp-Lys-Leu-Ala-Lys sequence, in which the RGD homing mot...

Disruption of rack1 suppresses SHH-type medulloblastoma formation in mice.

Sep 06, 2021

Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH-MB) is one of the major subtypes of MB in the clinic. Howeve...

High expression of Toll-like receptor 7 is a survival factor in pediatric medulloblastoma.

Sep 06, 2021

Medulloblastoma is an embryonal brain tumor that predominantly occurs in childhood with a wide histological and molecular variability. Our aim was to investigate the expression of Toll-like receptors ...

Perioperative Glycemia Management in Patients Undergoing Craniotomy for Brain Tumor Resection: a Global Survey of Neuroanesthesiologists' Perceptions and Practices.

Sep 06, 2021

There is currently a paucity of clinical evidence that guides perioperative glycemia management in patients undergoing craniotomy for brain tumor resection. The purpose of this study was to better und...

Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas.

Aug 26, 2021

The blood-brain barrier (BBB) plays important roles in brain tumor pathogenesis and treatment response, yet our understanding of its function and heterogeneity within or across brain tumor types remai...

Brain and other central nervous system tumor statistics, 2021.

Aug 26, 2021

Brain and other central nervous system (CNS) tumors are among the most fatal cancers and account for substantial morbidity and mortality in the United States. Population-based data from the Central Br...

Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.

Aug 26, 2021

The mechanism of vulnerability to pediatric low-grade gliomas (pLGGs)-the most common brain tumor in children-during development remains largely unknown. Using mouse models of neurofibromatosis type 1...

Etiology and Outcomes of Acquired Pediatric Sixth Nerve Palsies.

Aug 23, 2021

Acquired sixth nerve (CN6) palsies in children may be benign or associated with an underlying neurologic condition. In children who presented with isolated (no associated neurologic or ophthalmic symp...

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.

Aug 23, 2021

Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular ori...

Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner.

Aug 23, 2021

There are numerous investigated factors that limit brain cancer treatment efficacy such as ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of a therapeuti...

Multiple brain abscesses presented with monoparesis in a patient with lung abscess mimicking lung cancer.

Aug 19, 2021

Multiple brain abscesses associated with the lung mass require differential diagnosis from cancerous diseases. Here, we report a rare case of multiple brain abscesses originating from a lung abscess. ...

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin).

Aug 19, 2021

Glioblastoma is a highly malignant brain tumor with no curative treatment options, and immune checkpoint blockade has not yet shown major impact. We hypothesized that drugs targeting mitosis might imp...

Phenotypic changes on central nervous system (CNS) tumor cell lines cultured in vitro 2D and 3D models and treated with cisplatin.

Aug 19, 2021

Despite aggressive therapy, most patients with brain tumors present disease relapse due to the cellular and molecular nature of these tumors. One of the models that best explains the heterogeneity obs...

Ventriculomegaly and postoperative lateral/third ventricular blood as predictors of cerebrospinal fluid diversion following posterior fossa tumor resection.

Aug 16, 2021

Postoperative hydrocephalus occurs in one-third of children after posterior fossa tumor resection. Although models to predict the need for CSF diversion after resection exist for preoperative variable...

Methods for Intratumoral Microdialysis Probe Targeting and Validation in Murine Brain Tumor Models.

Aug 16, 2021

Microdialysis is a well validated sampling technique that can be used for pharmacokinetic studies of oncological drugs targeting the central nervous system. This technique has also been applied to eva...

SCAMP4 is a novel prognostic marker and correlated with the tumor progression and immune infiltration in glioma.

Aug 16, 2021

Glioma is the most prevalent brain tumor with high mortality and morbidity and the prognosis of patients remain very poor. Glioma therapy is largely limited by the extraordinary invasive capability in...

Recurrent Glioma: Does Qualitative Simultaneous 18F-DOPA PET/mp-MRI Improve Diagnostic Workup? An Initial Experience.

Aug 12, 2021

Neuroimaging modalities such as contrast-enhanced MRI and PET provide significant insight in the evaluation of gliomas. However, their reliability in successfully differentiating the tumor recurrence ...

Rule Perseveration during Task-Switching in Brain Tumor: A Severe Form of Task-Setting Impairment.

Aug 12, 2021

It has been proposed that at least two distinct processes are engaged during task-switching: reconfiguration of the currently relevant task-set and interference resolution arising from the competing t...

Molecular characterization of the anticancer properties associated with bee venom and its components in glioblastoma multiforme.

Aug 12, 2021

Glioblastoma multiforme (GBM) is a frequent form of malignant glioma. Strategic therapeutic approaches to treat this type of brain tumor currently involves a combination of surgery, radiotherapy and c...

Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy.

Aug 09, 2021

Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I-IV) with increa...