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Brain Cancer Oncology

Glioblastoma in adolescents and young adults: An age-based comparative study from Jordan over a 17-year period.

May 13, 2021

Glioblastoma (GBM) is the most common primary brain tumor. Epidemiologic studies on GBM are rarely reported in the special age group of adolescents and young adults (AYA) in comparison to other age gr...

Growing up after childhood cancer: maturity and life satisfaction in young adulthood.

May 10, 2021

Young individuals face a variety of developmental tasks as they mature into adulthood. For survivors of childhood cancer, growing up may be more difficult due to their illness and late effects from tr...

Depression and ability to work after vestibular schwannoma surgery: a nationwide registry-based matched cohort study on antidepressants, sedatives, and sick leave.

May 10, 2021

In patients with vestibular schwannomas (VS), tumor control is often achieved, and life expectancy is relatively good. The main risks of surgical treatment are hearing loss and facial nerve function. ...

Clinical features and surgical results of pediatric pleomorphic xanthoastrocytoma: analysis of 17 cases with a literature review.

May 10, 2021

Pediatric pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. To date, there are very few studies dedicated to this kind of pediatric tumor. The aim of this study was to investigate the clinico...

Telmisartan attenuates human glioblastoma cells proliferation and oncogenicity by inducing the lipid oxidation.

May 06, 2021

Glioblastoma (GBM) is one of the most common primary brain tumors, which accounts up to 80% of malignant brain tumors and the 5-year relative survival rate is below 5%. Recent studies showed that the ...

Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells.

May 06, 2021

Treatment for the lethal primary adult brain tumor glioblastoma (GBM) includes the chemotherapy temozolomide (TMZ), but TMZ resistance is common and correlates with promoter methylation of the DNA rep...

Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data.

May 06, 2021

Brain tumors, a group of heterogeneous diseases, are the second most common cancer and the leading cause of cancer-related deaths in children. Insight into the prognosis of pediatric brain tumor survi...

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles.

May 03, 2021

RNA-based therapies offer unique advantages for treating brain tumors. However, tumor penetrance and uptake are hampered by RNA therapeutic size, charge, and need to be "packaged" in large carriers to...

Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery.

May 03, 2021

Brain awake surgery with cognitive monitoring for tumor removal has become a standard of treatment for functional purpose. Yet, little attention has been given to patients' interpretation and awarenes...

TLR4 expression and functionality are downregulated in glioblastoma cells and in tumor-associated macrophages: a new mechanism of immune evasion?

May 03, 2021

Glioblastoma (GB) is the most common and aggressive form of primary brain tumor, in which the presence of an inflammatory environment, composed mainly by tumor-associated macrophages (TAMs), is relate...

Drug target ranking for glioblastoma multiforme.

Apr 29, 2021

Glioblastoma Multiforme, an aggressive primary brain tumor, has a poor prognosis and no effective standard of care treatments. Most patients undergoing radiotherapy, along with Temozolomide chemothera...

Risk of early failure of VP shunts implanted for hydrocephalus after craniotomies for brain tumors in adults.

Apr 29, 2021

Risks and survival times of ventriculoperitoneal (VP) shunts implanted due to hydrocephalus after craniotomies for brain tumors are largely unknown. The purpose of this study was to determine the over...

High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity.

Apr 29, 2021

High-grade astrocytoma with piloid features (HGAP) is a recently described brain tumor entity defined by a specific DNA methylation profile. HGAP has been proposed to be integrated in the upcoming Wor...

Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.

Apr 26, 2021

Although radiation therapy (RT) is a common treatment for pediatric brain tumors, it is associated with detrimental long-term effects such as impaired cognition, vascular injury, and increased stroke ...

Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells.

Apr 26, 2021

Glioblastoma multiforme (GBM), also known as grade IV astrocytoma, represents the most aggressive primary brain tumor. The complex genetic heterogeneity, the acquired drug resistance, and the presence...

Visual interpretability in 3D brain tumor segmentation network.

Apr 26, 2021

Medical image segmentation is a complex yet one of the most essential tasks for diagnostic procedures such as brain tumor detection. Several 3D Convolutional Neural Network (CNN) architectures have ac...

Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases.

Apr 22, 2021

PTEN and p16 frequently undergo (epi)genetic aberrations in melanoma resulting in decreased, or absent, protein levels. We investigated the prognostic significance of these tumor suppressor genes in m...

Identification of Dysregulated microRNAs in Glioma Using RNA-sequencing.

Apr 22, 2021

Glioma is the most common malignant brain tumor in central nervous system. Despite advances in the treatment of glioma such as surgery and chemoradiotherapy, most patients are easy to relapse, resulti...

A novel nomogram for predicting the risk of epilepsy occurrence after operative in gliomas patients without preoperative epilepsy history.

Apr 22, 2021

Epilepsy is a common complication in glioma patients after undergoing brain tumor surgery combined with chemotherapy and/or radiotherapy. Whether antiepileptic drug prophylaxis could be used in these ...

Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress.

Apr 19, 2021

Asparagine synthetase (ASNS) is a gene on the long arm of chromosome 7 that is copy number amplified in the majority of glioblastomas. ASNS copy number amplification is associated with a significantly...