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Brain Cancer Oncology

A Cohort Study on Prognostic Factors for Laser Interstitial Thermal Therapy Success in Newly Diagnosed Glioblastoma.

Jun 24, 2021

Laser interstitial thermal therapy (LITT) is a promising approach for cytoreduction of deep-seated gliomas. However, parameters contributing to treatment success remain unclear.To identify extent of a...

[Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas].

Jun 24, 2021

To evaluate the possibilities of dynamic preoperative C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults.The study included 74 patients aged 48±14 years w...

Concurrence of craniopharyngioma and meningioma: a case report and systematic review of the literature.

Jun 17, 2021

Craniopharyngioma (CPG) is a benign epithelial tumor that originates from Rathke's pouch. Meningiomas (MNG) are neoplasms of meningothelial cell. The patient is a 42-year-old female who presented with...

3D brain glioma segmentation in MRI through integrating multiple densely connected 2D convolutional neural networks.

Jun 17, 2021

To overcome the computational burden of processing three-dimensional (3D) medical scans and the lack of spatial information in two-dimensional (2D) medical scans, a novel segmentation method was propo...

Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.

Jun 17, 2021

Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this study is to ...

Implementation, relevance, and virtual adaptation of neuro-oncological tumor boards during the COVID-19 pandemic: a nationwide provider survey.

Jun 14, 2021

Neuro-oncology tumor boards (NTBs) hold an established function in cancer care as multidisciplinary tumor boards. However, NTBs predominantly exist at academic and/or specialized centers. In addition ...

Clinical features, diagnosis, and survival analysis of dogs with glioma.

Jun 14, 2021

Gliomas in dogs remain poorly understood.To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumo...

Radiomic Based Machine Learning Performance for a Three Class Problem in Neuro-Oncology: Time to Test the Waters?

Jun 07, 2021

Prior radiomics studies have focused on two-class brain tumor classification, which limits generalizability. The performance of radiomics in differentiating the three most common malignant brain tumor...

Maximizing the potential of aggressive mouse tumor models in preclinical drug testing.

Jun 07, 2021

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing in ATRT. First, genetically quiet, ATRT is...

Virtual Reality during Brain Mapping for Awake-Patient Brain Tumor Surgery: Proposed Tasks and Domains to Test.

Jun 07, 2021

Virtual Reality (VR) use in healthcare has increased over the past few decades, with its utility expanding from a teaching tool to a highly reliable neuro-technology adjunct in multiple fields includi...

Can Preoperative Mapping with Functional MRI Reduce Morbidity in Brain Tumor Resection? A Systematic Review and Meta-Analysis of 68 Observational Studies.

Jun 03, 2021

Background Preoperative functional MRI (fMRI) is one of several techniques developed to localize critical brain structures and brain tumors. However, the usefulness of fMRI for preoperative surgical p...

Determination of Brain Tumor Recurrence using C-methionine Positron Emission Tomography after Radiotherapy.

Jun 03, 2021

We conducted a prospective multicenter trial to compare the usefulness of C-methioinine (MET) and F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for identifying tumor recurrence. Pati...

Transfer learning enhanced generative adversarial networks for multi-channel MRI reconstruction.

Jun 03, 2021

Deep learning based generative adversarial networks (GAN) can effectively perform image reconstruction with under-sampled MR data. In general, a large number of training samples are required to improv...

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.

May 31, 2021

Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recen...

Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models.

May 31, 2021

Medulloblastoma is the most common malignant cerebellar tumor in children. Recent technological advances in multi-layered omics data analysis have revealed four molecular subgroups of medulloblastoma ...

Difficulties encountered by physicians and mental health professionals in evaluating and caring for affective and behavioral problems in pediatric brain tumor survivors.

May 17, 2021

Pediatric brain tumor survivors (PBTS) present a high risk for emotional and behavioral disorders. When addressing these difficulties, differences in study designs; variety of and disagreement about d...

Electroporation-based Therapy for Brain Tumors: A Review.

May 17, 2021

Electroporation-based therapy (EBT), as a high-voltage-pulse technology has been prevalent with favorable clinical outcomes in the treatment of various solid tumors. The aim of this review paper is to...

Acquisition of Basic Micro Neurosurgical Skills Using Cavitron Ultrasonic Aspirator in Low Cost Readily Available Models: The Egg Model.

May 17, 2021

Attainment of neuromicrosurgical skills is a challenge in teaching hospitals throughout training. Models that mimic the workflow as well as haptics are time-consuming, expensive, unsuitable to serve a...

Survival of brain tumour patients with epilepsy.

May 13, 2021

Pro-tumorigenic electrochemical synapses between neurons and brain tumor cells in pre-clinical studies suggest unfavorable effects of epilepsy on patient survival. We investigated associations of epil...

Current landscape and future prospects of radiation sensitizers for malignant brain tumors: a systematic review.

May 13, 2021

Radiation therapy (RT) is the cornerstone of management of malignant brain tumors, but its efficacy is limited in hypoxic tumors. Although numerous radiosensitizer compounds have been developed to enh...