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Brain Cancer Oncology

Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression.

Apr 15, 2021

Methods for quantifying gene expression and chromatin accessibility in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been tec...

Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain.

Apr 15, 2021

Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generall...

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy.

Apr 15, 2021

Clinical treatment of malignant glioma remains a major challenge due to high infiltrative growth and chemotherapeutic resistance of tumors and the presence of the blood brain barrier (BBB). Advanced n...

What Every Neuropathologist Needs to Know: Practical Aspects and Pitfalls in Molecular Diagnosis of Brain Tumors.

Apr 12, 2021

Molecular testing has become part of the routine diagnostic workup of brain tumors after the implementation of integrated histomolecular diagnoses in the 2016 WHO classification update. It is importan...

Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.

Apr 12, 2021

Language fMRI has become an integral part of the planning process in brain surgery. However, fMRI may suffer from confounding factors both on the patient side, as well as on the provider side. In this...

A novel analytical population TCP model includes cell density and volume variations: application to canine brain tumor.

Apr 12, 2021

Tumor control probability (TCP) models based on Poisson statistics characterize the distribution of surviving clonogens. Thus enabling the calculation of TCP for individuals. In order to mathematicall...

Multiband diffusion tensor imaging for presurgical mapping of motor and language pathways in patients with brain tumors.

Apr 08, 2021

Assessment of the essential white matter fibers of arcuate fasciculus and corticospinal tract (CST), required for preoperative planning in brain tumor patients, relies on the reliability of diffusion ...

Discovery of a rare fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib.

Apr 08, 2021

Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routin...

Assessing Neuropsychological Phenotypes of Pediatric Brain Tumor Survivors.

Apr 08, 2021

Pediatric brain tumor survivors (PBTS) are at risk for both neurocognitive impairments and psychological difficulties, yet these two domains have historically been discretely examined, with assessment...

The impact of gender on long-term outcomes following supratentorial brain tumor resection.

Apr 05, 2021

Gender is a known social determinant of health which has been linked disparities in medical care. This study intends to assess the impact of gender on 90-day and long-term morbidity and mortality outc...

Pain Quality Among Hospitalized Postcraniotomy Brain Tumor Patients.

Apr 05, 2021

The aim of this study was to describe how persons given a diagnosis of a brain tumor who have had a craniotomy describe the quality of their pain after surgery.A qualitative descriptive design was use...

Diagnosis and Management of Neuroendocrine Disorders of Survivors of Brain Tumors.

Apr 05, 2021

Advances in the treatment of brain tumors have led to an increase in the number of survivors of this disease. Consequently, the long-term complications associated with past and current treatments are ...

Dentate Nucleus Signal Intensity Changes in Children with Adrenoleukodystrophy in Comparison to Primary Brain Tumor with and without Radiotherapy after Gadobutrol Administration.

Apr 01, 2021

To determine whether cerebral adrenoleukodystrophy (cALD) or brain irradiation in patients with primary brain tumor affects T1-weighted imaging (T1WI) signal intensity (SI) of the dentate nucleus (DN)...

Risk Factors of Persistent Hydrocephalus in Children with Brain Tumor: A Retrospective Analysis.

Apr 01, 2021

Hydrocephalus is one of the main complications of brain tumors in children, being present in about 50% of cases at the time of the tumor diagnosis and persisting up to 10-40% of cases after surgical r...

Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma.

Mar 29, 2021

Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and ...

Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery.

Mar 29, 2021

The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumo...

Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study.

Mar 29, 2021

Meningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and po...

Coordinated Methyl Readers: Functional Communications in Cancer.

Mar 25, 2021

Methylation is a major post-translational modification (PTM) generated by methyltransferase on target proteins; it is recognized by the epigenetic reader to expand the functional diversity of proteins...

A first-generation pediatric cancer dependency map.

Mar 25, 2021

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in...

Randomized Multi-Reader Evaluation of Automated Detection and Segmentation of Brain Tumors in Stereotactic Radiosurgery with Deep Neural Networks.

Mar 25, 2021

Stereotactic radiosurgery (SRS), a validated treatment for brain tumors, requires accurate tumor contouring. This manual segmentation process is time-consuming and prone to substantial inter-practitio...