When three-dose schedule antibody concentrations are reached in patients with blood cancer who are immunocompromised, they are comparable to that of healthy controls after two doses. ...
Inherited germline variation can predispose individuals to cancer and affect the biology of the disease as it grows. The rare germline ataxia telangiectasia-mutated (ATM) variants found ...
For patients with CLL, clinically significant improvements linked with a 12-week HIIT+RT exercise program support its role in HRQOL. Older people living with chronic lymphocytic leuke...
The best course of treatment for certain patients with acute myeloid leukemia (AML) is allogeneic hematopoietic stem cell transplantation (allo-HSCT), which depends on a "graft-versus-leukem...
Multiple analyses and investigations into the molecular mechanisms behind ABO blood type antigen changes in oncogenesis have been performed. Researchers found that there is a lack of publish...
The characteristic of both cancer and cell division is altered metabolism. For example, chronic lymphocytic leukemia (CLL) cells move between lymph nodes (LNs) and peripheral blood (PB), whe...
Due to concerns about poor response and treatment-related neurotoxicity, few studies have documented chimeric antigen receptor (CAR) T-cell therapy for patients with B-cell acute lymphoblast...
Physicians should have discussions with their patients with CML who are considering discontinuing a TKI and those who experience pain after stopping a TKI. “Past clinical trials hav...
Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 exp...
Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute l...
WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine methyltransferase complex, is critically involved in oncogenesis and represents an attractive onco-target. Inhibitors...
Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a ly...
Up-regulation of immune checkpoint ligands is considered as one of the most important immune escape mechanisms in acute myeloid leukemia (AML). Herein, we investigate a relationship between ...
A four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (...
As chimeric antigen receptor T (CAR-T) cell therapy targeting CD19 has shown favorable outcomes in patients with relapsed or refractory (r/r) mature B-cell lymphomas and B-cell acute lymphob...
Lymphoid enhancer-binding factor 1 (LEF1) is a transcription factor involved in T-cell maturation and is usually absent in mature B-cells. Previous studies have shown aberrant LEF1 expressio...
B-cell leukemia/lymphoma 11B (BCL11B) is a transcription factor important for T-cell development and acts as a tumor suppressor gene in T-cell acute lymphoblastic leukemia. Here, we identifi...
The abnormal levels of uric acid (UA) in body fluids are associated with gout, type (II) diabetes, leukemia, Lesch-Nyhan syndrome, uremia, kidney damage, and cardiovascular diseases. Also, t...
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation. However, specific molecular mechan...
Neuroblastoma (NB) is a childhood cancer that often occurs in the sympathetic nervous system. Previous reports showed that long non-coding RNAs (lncRNAs) could affect the progress of NB, but...
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