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Leukemia

Managing Pain After Discontinuing Treatment for Leukemia

Jun 22, 2022

Physicians should have discussions with their patients with CML who are considering discontinuing a TKI and those who experience pain after stopping a TKI. “Past clinical trials have shown th...

Role of CDH23 as a prognostic biomarker and its relationship with immune infiltration in acute myeloid leukemia.

May 23, 2022

Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on...

C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction.

May 23, 2022

Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblast...

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.

May 09, 2022

WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine methyltransferase complex, is critically involved in oncogenesis and represents an attractive onco-target. Inhibitors targeting...

The dual role of autophagy in acute myeloid leukemia.

May 09, 2022

Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dep...

The Effects of PI3K/Akt/mTOR Signaling Pathway Inhibitors on the Expression of Immune Checkpoint Ligands in Acute Myeloid Leukemia Cell Line.

May 02, 2022

Up-regulation of immune checkpoint ligands is considered as one of the most important immune escape mechanisms in acute myeloid leukemia (AML). Herein, we investigate a relationship between the inhibi...

Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab.

May 02, 2022

A four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (73.6% of w...

A clinically applicable prediction model to improve T-cell collection in CAR-T cell therapy.

Apr 25, 2022

As chimeric antigen receptor T (CAR-T) cell therapy targeting CD19 has shown favorable outcomes in patients with relapsed or refractory (r/r) mature B-cell lymphomas and B-cell acute lymphoblastic leu...

Aberrant Expression of Lymphoid Enhancer-Binding Factor 1 (LEF1) in Hodgkin Lymphoma.

Apr 18, 2022

Lymphoid enhancer-binding factor 1 (LEF1) is a transcription factor involved in T-cell maturation and is usually absent in mature B-cells. Previous studies have shown aberrant LEF1 expression as a sen...

Oncogenic isoform switch of tumor suppressor BCL11B in adult T-cell leukemia/lymphoma.

Apr 18, 2022

B-cell leukemia/lymphoma 11B (BCL11B) is a transcription factor important for T-cell development and acts as a tumor suppressor gene in T-cell acute lymphoblastic leukemia. Here, we identified BCL11B ...

Liquid crystal-based sensitive and selective detection of uric acid and uricase in body fluids.

Apr 11, 2022

The abnormal levels of uric acid (UA) in body fluids are associated with gout, type (II) diabetes, leukemia, Lesch-Nyhan syndrome, uremia, kidney damage, and cardiovascular diseases. Also, the presenc...

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics and DNA repair.

Mar 28, 2022

The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation. However, specific molecular mechanisms contr...

Long noncoding RNA LINC01296 regulates the cell proliferation, migration and invasion in neuroblastoma.

Mar 21, 2022

Neuroblastoma (NB) is a childhood cancer that often occurs in the sympathetic nervous system. Previous reports showed that long non-coding RNAs (lncRNAs) could affect the progress of NB, but the mecha...

PRMT5 regulates ATF4 transcript splicing and oxidative stress response.

Mar 21, 2022

Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology targ...

Mapping the cancer imaging research landscape: which cancers are more and which cancers are less frequently investigated?

Mar 14, 2022

To investigate the proportion of published imaging studies relative to incidence and mortality rate per cancer type.From a random sample of 2500 articles published in 2019 by the top 25 imaging-relate...

The 7-Hydroxyflavone attenuates chemotherapy-induced neuropathic pain by targeting inflammatory pathway.

Mar 14, 2022

Vincristine and paclitaxel are widely used chemotherapeutic drugs for the treatment of brain tumors, breast cancer, leukemia, lymphomas, and malignant solid tumors. Though, these drugs are associated ...

ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia.

Mar 07, 2022

ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but their mechanistic role in leukemogenesis and lineage ambiguity is poorly understood. Using viral expressi...

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Feb 28, 2022

A series of novel non-covalent peptidomimetic proteasome inhibitors possessing bulky group at the C-terminus and N-alkylation at the N-terminus were designed with the aim to increase metabolic stabili...

The expression of Slit2 and Robo1 increased during retinoic acid syndrome in acute promyelocytic leukemia and impacted differentiated cell migration.

Feb 21, 2022

Retinoic acid syndrome (RAS) is a serious complication developed during the induction therapy of acute promyelocytic leukemia (APL). Cytokines and differentiated cells migration play important roles i...

Osteopontin is required for the maintenance of leukemia stem cells in acute myeloid leukemia.

Feb 21, 2022

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic disorder with a poor prognosis. The clinical significance of Leukemia stem cells (LSCs) plays an important role in the generation of AML a...