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Lymphoma

Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices.

May 16, 2022

We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping them with antibodies for efficient targeting of lymphoma cells...

Assessment of therapeutic effect of CD20-targeted immunoliposome in primary central nervous system lymphoma.

Apr 25, 2022

Primary central nervous system lymphoma (PCNSL) is a form of extranodal non-Hodgkin's B-cell lymphoma limited to the CNS. The treatment of PCNSL is ineffective partly due to the blood-brain barrier (B...

#VisualAbstract: Odronextamab shows promising clinical activity in patients with relapsed or refractory B-cell non-Hodgkin lymphoma

Apr 24, 2022

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A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4 lymphoma cells without toxicity in immunocompromised and immunocompetent mice.

Apr 18, 2022

High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make an urgent need to develop new therapies f...

A content-based image retrieval system for the diagnosis of lymphoma using blood micrographs: An incorporation of deep learning with a traditional learning approach.

Apr 18, 2022

Lymphomas, or cancers of the lymphatic system, account for around half of all blood cancers diagnosed each year. Lymphoma is a condition that is difficult to diagnose, and accurate diagnosis is critic...

Real-World Treatment Patterns After CD19-Directed CAR T Cell Therapy Among Patients with Diffuse Large B Cell Lymphoma.

Apr 11, 2022

CD19-directed chimeric antigen receptor T cells (CAR T) are approved for treatment of adults with relapsed/refractory diffuse large B cell lymphoma (DLBCL) following at least two lines of therapy.Thi...

t(10;12)(q24;q15): A new cytogenetic marker in hematological malignancies.

Apr 11, 2022

Cytogenetic studies have played a crucial role in the discovery of genes involved in several diseases. In the field of oncohematology, cytogenetics is still necessary for the classification and progno...

Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease.

Apr 04, 2022

Cutaneous T-cell lymphoma (CTCL) patients often suffer from recurrent skin infections and profound immune dysregulation in advanced disease. The gut microbiome has been recognized to influence cancers...

Translating the Biology of Diffuse Large B-cell Lymphoma Into Treatment.

Mar 21, 2022

Diffuse large B-cell lymphoma (DLBCL) is characterized by clinical and molecular heterogeneity; however, this heterogeneity is rarely taken into account by standard-of-care treatment approaches. While...

LncRNA ZFPM2-AS1 drives the progression of nasopharyngeal carcinoma via modulating the downstream miR-3612/DTL signaling.

Mar 14, 2022

LncRNA ZFPM2-AS1 has been illuminated to function as a carcinogenic driver in various human cancers. Whereas, the role of ZFPM2-AS1 in nasopharyngeal carcinoma (NPC) remains puzzled. To further unders...

Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma.

Mar 07, 2022

Cutaneous T-cell lymphoma is a rare cancer of skin-homing T-cells. A subgroup of patients develops large cell transformation with rapid progression to an aggressive lymphoma. Here, we investigated the...

Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma.

Mar 07, 2022

Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare lymphoma of natural killer (NK) cell origin with poor clinical outcomes. Here we used phenotypic and molecular profiling, inclu...

Feasibility of Deriving Health State Utilities in Mycosis Fungoides Cutaneous T-Cell Lymphoma Using Mapping Algorithms.

Feb 21, 2022

A prospective, observational, US-based study (PROVe) used three questionnaires (Pruritus-VAS, Skindex-29, MF/SS-CTCL QoL) to assess quality of life in patients diagnosed with mycosis fungoides cutaneo...

HIV-related plasmablastic lymphoma causing extensive bone destruction in the mandible.

Feb 14, 2022

Plasmablastic lymphoma (PBL) is a rare subtype of large B-cell lymphoma commonly associated with HIV infection. HIV-related PBL has a dismal prognosis. The aggressive clinical course of the disease ma...

Toxicological mechanism of large amount of copper supplementation: Effects on endoplasmic reticulum stress and mitochondria-mediated apoptosis by Nrf2/HO-1 pathway-induced oxidative stress in the porcine myocardium.

Feb 14, 2022

Copper (Cu) is an essential micronutrient that is required by all living organisms. However, Cu can also be a potentially toxic metal if excessive dietary supplementation occurs. The current study aim...

Impact of Human T-Cell Lymphotropic Virus Type 1 and 2 Infection on Survival Following Stem Cell Transplantation.

Feb 07, 2022

Human T-Cell Lymphotropic Virus Types 1 and 2 (HTLV-1/2) are delta retroviruses. HTLV-1 may lead to complications including adult T-cell leukemia-lymphoma (ATLL) and HTLV-1-associated myelopathy (HAM)...

Current Frontline Treatment of Diffuse Large B-Cell Lymphoma.

Jan 31, 2022

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, is an aggressive and biologically heterogeneous disease. Risk stratification and treatment algorithms vary based...

Impact of timing and precision of histopathological diagnosis on outcomes of patients with Burkitt Lymphoma and High-Grade B-Cell Lymphoma.

Jan 31, 2022

Burkitt Lymphoma (BL) and Diffuse Large B-Cell Lymphoma (DLBCL) are aggressive B-Cell Non-Hodgkin Lymphomas (B-NHL) with a generally favorable prognosis after immunochemotherapy. The outcome of BL is ...

Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray.

Jan 24, 2022

Proteins secreted by cells play significant roles in mediating many physiological, developmental, and pathological processes due to their functions in intra/intercellular communication and signaling. ...

TSLP up-regulates inflammatory responses through induction of autophagy in T cells.

Jan 10, 2022

Thymic stromal lymphopoietin (TSLP), a type I cytokine belonging to the IL-2 cytokine family, promotes Th2-mediated inflammatory responses. The aim of this study is to investigate whether TSLP increas...