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Pain General

Maintaining musculoskeletal health using a behavioural therapy approach: a population-based randomised controlled trial (the MAmMOTH Study).

Feb 04, 2021

Cognitive-behavioural therapy (CBT) has been shown to be effective in the management of chronic widespread pain (CWP); we now test whether it can onset among adults at high risk.A population-based ra...

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Feb 04, 2021

To explore the relationship between symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM). The hypothesis predicated that there would be no significant differ...

Altered central pain processing in fibromyalgia-A multimodal neuroimaging case-control study using arterial spin labelling.

Feb 04, 2021

Fibromyalgia is characterized by chronic pain and a striking discrepancy between objective signs of tissue damage and severity of pain. Function and structural alterations in brain areas involved in p...

A Clinical Trial of a Video Intervention Targeting Opioid Disposal After General Surgery: A Feasibility Study.

Feb 04, 2021

The opioid epidemic continues and although some initiatives have shown promise in reducing the number of opiates prescribed, few studies have focused on education of general surgery patients about hom...

A randomized controlled trial of the X-Stop interspinous distractor device versus laminectomy for lumbar spinal stenosis with 2-year quality-of-life and cost-effectiveness outcomes.

Feb 04, 2021

Lumbar spinal stenosis (LSS) is a common and debilitating condition that is increasing in prevalence in the world population. Surgical decompression is often standard treatment when conservative measu...

Spine Examination during COVID-19 Pandemic via Video Consultation.

Feb 04, 2021

During the current COVID-19 pandemic video consultations are increasingly common in order to minimize the risk of infection for staff and patients. The aim of this study was to evaluate the feasibilit...

Double Oblique Osteotomy and Rotation of the trapeziometacarpal Joint (DOOR procedure).

Feb 04, 2021

The double oblique osteotomy with rotation of the trapeziometacarpal (TMC) joint procedure (DOOR procedure) is a surgical technique conceived to treat non-traumatic TMC instability, often responsible ...

Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes.

Feb 04, 2021

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive tissue, leading to c...

Genetic association analysis of ATG16L1 rs2241880, rs6758317 and ATG16L2 rs11235604 polymorphisms with rheumatoid arthritis in a Chinese population.

Feb 04, 2021

This study was performed to test whether ATG16L1 rs2241880, rs6758317 and ATG16L2 rs11235604 polymorphisms were associated with RA and further examine the genetic interaction between ATG16L1 and ATG16...

A proteome signature in dorsal root ganglia for acute incisional pain in mice.

Feb 04, 2021

After surgery, acute pain is still managed insufficiently and may lead to short- and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identif...

Assessing outcome in postoperative pain trials: are we missing the point?A systematic review of pain-related outcome domains reported in studies early after total knee arthroplasty.

Feb 04, 2021

The management of acute postoperative pain remains suboptimal. Systematic reviews and Cochrane analysis can assist with collating evidence about treatment efficacy, but the results are limited in part...

A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.

Feb 04, 2021

Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics d...

Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.

Feb 01, 2021

It is increasingly recognized that non-opioid analgesia important analgesia in the perioperative period. Specifically, NSAIDs (nonsteroidal anti-inflammatory drugs) have been touted as an adjunct or e...

Pain Management Strategies Following Anterior Cruciate Ligament Reconstruction - A Systematic Review with Network Meta-Analysis.

Feb 01, 2021

The purpose of this study is to systematically review the randomized controlled trials (RCTs) that evaluate various pain control interventions post-anterior cruciate ligament reconstruction (ACLR), in...

Association of opioid misuse with anxiety and depression: A systematic review of the literature.

Feb 01, 2021

The opioid epidemic is a public health problem associated with a host of negative outcomes. Although clinicians recognize covariation between opioid misuse with anxiety and depressive symptoms and dis...

Changes in headache characteristics with oral appliance treatment for obstructive sleep apnea.

Feb 01, 2021

Changes in headache characteristics in obstructive sleep apnea (OSA) patients following oral appliance treatment was investigated for the first time. Thirteen OSA patients with headaches treated with ...

Prevalence and characteristics of cutaneous allodynia in probable migraine.

Feb 01, 2021

Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of ...

Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study.

Feb 01, 2021

In this study we used nitroglycerin (NTG)-induced migraine attacks as a translational human disease model. Static and dynamic functional connectivity (FC) analyses were applied to study the associated...

Posthypnotic Amnesia in Hypnotizability Assessment: Validation of a New Scoring System for the Hypnotic Induction Profile.

Feb 01, 2021

The Hypnotic Induction Profile (HIP) is a standardized assessment of hypnotizability featuring a validated 0-10 scoring system, that does not factor in posthypnotic amnesia. Using confirmatory factor ...

Augmentation of EMDR with multifocal transcranial current stimulation (MtCS) in the treatment of fibromyalgia: study protocol of a double-blind randomized controlled exploratory and pragmatic trial.

Feb 01, 2021

Fibromyalgia (FM) is a generalized, widespread chronic pain disorder affecting 2.7% of the general population. In recent years, different studies have observed a strong association between FM and psyc...

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