Jan 14, 2021

Enhanced recovery (ERAS) pathways can help hospitals maximize the incentives of bundled payment models while maintaining high-quality patient care. A key component of an enhanced recovery pathway is t...

Jan 14, 2021

Cauda Equina Syndrome (CES) occurs due to compression of the lumbar and sacral nerve roots and is considered a surgical emergency. Although the condition is relatively rare, the associated morbidity c...

Jan 14, 2021

IL-6-triggered Th17 cell expansion is responsible for the pathogenesis of many immune diseases including rheumatoid arthritis (RA). Traditionally, IL-6 induces Th17 cell differentiation through JAK-ST...

Jan 14, 2021

Although placebo effect sizes in clinical trials of chronic pain treatments have been increasing, it remains unknown if characteristics of individuals' thoughts or prior experiences can reliably infer...

Jan 14, 2021

Pain puts patients at risk for developing psychiatric conditions such as anxiety and depression. Pre-clinical mouse models of pain-induced affective behavior vary widely in methodology and results, im...

Jan 14, 2021

The primary aim of this randomized clinical trial is to investigate the effects of ultrasound guided transversus abdominis plane (TAP) versus ultrasound guided trigger point injections (TPIs) on numer...

Jan 14, 2021

Low Back Pain (LBP) is commonly reported as a very frequent disorder in sports, but its prevalence in runners remains unclear.To determine the prevalence of LBP in a wide sample of Italian runners.A c...

Jan 14, 2021

Due to the elevated presence of cytokines, the expressions of metabolic enzymes and drug transporters are altered in rheumatoid arthritis (RA). Given the high incidence of diabetes in patients with RA...

Jan 14, 2021

Inflammation is an underlying cause of or a contributing factor to a number of chronic conditions, including hypertension, insulin resistance, arthritis, and cognitive disorders. A chronic inflammator...

Jan 11, 2021

COVID-19 community mitigation measures (e.g., stay-at-home orders) may worsen mental health and substance use-related harms such as opioid use disorder and overdose and limit access to medications for...

Jan 11, 2021

Headache is an important manifestation during SARS-CoV-2 infection. In this study, we aim to identify factors associated with headache in COVID-19 and headache characteristics.This case-control study ...

Jan 11, 2021

Migraine is a cyclic disorder but also a chronic pain condition. Left-right recognition tasks have been shown to be impaired in patients with chronic pain.To investigate whether laterality judgements ...

Jan 11, 2021

To evaluate the sensitivity and specificity of the 6-item Identify Chronic Migraine screener (ID-CM[6]), designed to improve the detection of chronic migraine (CM).CM is often undertreated and underdi...

Jan 11, 2021

Insomnia is a chronic condition that occurs a minimum of three times per week over a period of three or more subsequent months. There are multiple causes of insomnia, and even though it is considered ...

Jan 11, 2021

Rheumatic diseases, such as juvenile idiopathic arthritis (JIA), are typically associated with acute pain mainly caused by inflammation. Chronic pain is described as pain lasting at least 3 months. In...

Jan 11, 2021

Millions of opioid and benzodiazepine prescriptions are dispensed near end-of-life. After death, patients' unused prescription pills belong to family members, who often save rather than dispose of the...

Jan 11, 2021

Prescription opioids accounted for the majority of opioid-related deaths in the United States prior to 2010, and continue to contribute to opioid misuse and mortality. We used a novel dataset to inves...

Jan 11, 2021

Characterization of sociodemographic and clinical aspects of patients admitted to the Orthopedic Department (OD) after observation in the Emergency Room (ER) with the diagnosis of septic arthritis (SA...

Jan 11, 2021

Pain and depression are episodic conditions that might take a chronic course. They are clearly related, but information on how they influence each other in the process of chronification is limited. Pa...

Jan 11, 2021

During inflammation or tissue injury, pro-inflammatory mediators attract migratory monocytes to inflammatory sites and monocyte-to-macrophage differentiation occurs to activate macrophages. We report ...