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Pain General

Diagnostic issues in difficult-to-treat rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis.

Feb 01, 2021

To summarise the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) informing the EULAR recommendations for the management of D2T RA.A systematic literature review (SLR)...

Empathy, The Best Medicine? How Doctors can Help Patients Remember More Information and Make Better-Informed Decisions

Jan 29, 2021

The expression “It shouldn’t have to happen to you to matter to you” has been making the rounds on social media platforms lately. In my opinion, it’s a great way to define empathy, our ability...

Anxiety sensitivity and substance use: Differential levels across individuals primarily using opioids, cannabis, or stimulants.

Jan 28, 2021

The purpose of the current study was to compare levels of anxiety sensitivity (AS) across a treatment-seeking sample of individuals primarily using opioids, stimulants, or cannabis. Consistent with th...

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...

Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland.

Jan 28, 2021

The paper describes the first three deaths reported in Europe involved in isotonitazene consumption, a potent benzimidazole derivate opioid consumed in the recreational drug scene. Isotonitazene powde...

Prevalence, Disability, and Management Patterns of Migraine in Korea: Nationwide Survey Data from 2009 and 2018.

Jan 28, 2021

Identifying changes in the prevalence, disability, and management patterns of migraine is important for reducing the burden of this disease. However, data on the changes in these variables are scarce....

Psychometric validation and meaningful within-patient change of the Migraine-Specific Quality of Life questionnaire version 2.1 electronic patient-reported outcome in patients with episodic and chronic migraine.

Jan 28, 2021

To evaluate the measurement properties of all three domains of the Migraine-Specific Quality of Life questionnaire version 2.1 (MSQ v2.1) electronic patient-reported outcome (ePRO) to assess the funct...

Introduction of a smartphone based behavioral intervention for migraine in the emergency department.

Jan 28, 2021

To determine whether a smartphone application (app) with an electronic headache diary and a progressive muscle relaxation (PMR) intervention is feasible and acceptable to people presenting to the Emer...

Relevance of Religiosity for Coping Strategies and Disability in Patients with Fibromyalgia Syndrome.

Jan 28, 2021

Coping strategies are essential for the outcome of chronic pain. This study evaluated religiosity in a cohort of patients with fibromyalgia syndrome (FMS), its effect on pain and other symptoms, on co...

The Prevalence of Fibromyalgia Among Medical Students at King Abdulaziz University: A Cross-Sectional Study.

Jan 28, 2021

Background and objective Fibromyalgia (FM) is a chronic, multifactorial pain condition. The latest literature suggests that genetic and environmental factors including continuous stress contribute sig...

The Search for Biomarkers in Fibromyalgia.

Jan 28, 2021

Fibromyalgia is the most common of the central sensitivity syndromes affecting 2-5% of the adult population in the United States. This pain amplification syndrome has enormous societal impact as measu...

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...

Comparative Cost-Effectiveness of Tofacitinib With Continuing Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for Active Rheumatoid Arthritis in South Korea.

Jan 28, 2021

The objective of this study was to evaluate the cost-effectiveness of initiating treatment with tofacitinib and subsequently incorporating it into a conventional synthetic disease-modifying anti-rheum...

The Quality of Online Resources Available to Patients Regarding Cannabidiol for Symptomatic Relief of Hip or Knee Arthritis is Poor.

Jan 28, 2021

This study aimed to assess the quality of online resources pertaining to cannabidiol (CBD) for the nonoperative management of hip and knee arthritis.Websites were identified on the three most popular ...

Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-α, IL-1β, IL-10 and IL-17A.

Jan 28, 2021

Biomarkers play a pivotal role in the management of rheumatoid arthritis (RA) by facilitating early diagnosis and 'treat to the target.' However, no gold standard biomarker has been identified for mon...

A proteome signature in dorsal root ganglia for acute incisional pain in mice.

Jan 28, 2021

After surgery, acute pain is still managed insufficiently and may lead to short- and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identif...

Assessing outcome in postoperative pain trials: are we missing the point?A systematic review of pain-related outcome domains reported in studies early after total knee arthroplasty.

Jan 28, 2021

The management of acute postoperative pain remains suboptimal. Systematic reviews and Cochrane analysis can assist with collating evidence about treatment efficacy, but the results are limited in part...

A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.

Jan 28, 2021

Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics d...

Anxiety, Depression, & Chronic Pancreatitis

Jan 20, 2021

Psychiatric comorbidities are prevalent in patients with chronic pancreatitis (CP) and associated with pain and reduced quality of life (QOL), Anna Evans Phillips, MD, MS, explains. “Prior studies h...

Peripheral nerve injury promotes morphine-seeking behavior in rats during extinction.

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...

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