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Pain General

Bleeding complications during pregnancy and delivery in haemophilia carriers and their neonates in Western France: An observational study.

Aug 27, 2020

Pregnancy, delivery and the postpartum period expose haemophilia carriers, as well as their potentially affected neonates to a high risk of haemorrhagic complications.To describe bleeding complication...

Flourensia fiebrigii S.F. Blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory.

Aug 27, 2020

Flourensia fiebrigii is a plant used in traditional medicine in the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory.The aim of this study was to analyze the...

Criteria Used for the Diagnosis of Myofascial Trigger Points in Clinical Trials on Physical Therapy: Updated Systematic Review.

Aug 27, 2020

To conduct an updated systematic review of diagnostic criteria for myofascial trigger points (MTrPs) used in clinical trials of physical therapy interventions from 2007 to 2019.MEDLINE and Physiothera...

Longitudinal Patterns of Pain Reporting among Community-dwelling Older Adults.

Aug 27, 2020

To identify and describe long-term trajectories of bothersome pain and activity-limiting pain in a population-based sample of older adults.We conducted a retrospective cohort study of 6783 community-d...

Placebo Response Reduction and Accurate Pain Reporting Training Reduces Placebo Responses in a Clinical Trial on Chronic Low Back Pain: Results from a Comparison to the Literature.

Aug 27, 2020

A literature review was conducted to compare placebo responses in a recent trial-which implemented an Accurate Pain Reporting (APR) and Placebo Response Reduction (PRR) training program-to placebo res...

Attentional bias to somatosensory stimuli in chronic pain patients: a systematic review and meta-analysis.

Aug 27, 2020

This systematic review and meta-analysis aimed to evaluate the evidence pertaining to attentional bias for painful and non-painful somatosensory stimuli in individuals with chronic pain. Eligible stud...

[Analysis of clinical features of vestibular migraine].

Aug 27, 2020

To analyze the clinical features of Vestibular migraine(VM) and provide evidence for its accurate diagnosis and medical identification of flight personnel. A total of 490 samples of VM patients we...

Alternative therapy of rheumatoid arthritis with a novel transdermal patch containing Siegesbeckiae Herba extract.

Aug 27, 2020

Siegesbeckiae Herba (SiH) is a traditional anti-rheumatic herbal medicine in China. A SiH derived product, Phynova Joint and Muscle Relief Tablets™, has been granted the UK license in 2015. Alt...

Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice.

Aug 27, 2020

Liriodendron chinense (Hemsl.) Sarg, known as the Chinese tulip tree, has a long history of cultivation and utilization in many Asia countries, especially in China to use in traditional Chinese medici...

Treating Fibromyalgia Pain With Lidocaine

Aug 26, 2020

Previous studies indicate that chronic pain, including fibromyalgia (FM), negatively impacts quality of life (QoL) for the reportedly affected 3%-6% of the world population. “There is supportive evi...

Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives.

Aug 24, 2020

Integrated behavioral paradigms such as nociceptive processing coupled to anti-nociceptive responsiveness include systemically-mediated states of alertness, vigilance, motivation, and avoidance. Withi...

Psychological factors associated with substance use initiation during the COVID-19 pandemic.

Aug 24, 2020

The 2019 outbreak of the novel coronavirus (COVID-19) has had a devastating impact. Given the on-going nature of the outbreak, the deleterious toll on mental health, including substance use, is unknow...

Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles.

Aug 24, 2020

To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2)...

Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation.

Aug 24, 2020

Osteoarthritis (OA), the most common form of arthritis, is characterized by chronic inflammation, degeneration of articular cartilage and whole joints. Local delivery by intra-articular (IA) injection...

A spider-venom peptide with multi-target activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome.

Aug 24, 2020

Chronic pain is a serious debilitating condition that affects ∼20% of the world's population. Currently available drugs fail to produce effective pain relief in many patients and have dose-limiting ...

The use and reporting of neonatal pain scales: a systematic review of randomized trials.

Aug 24, 2020

The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infan...

Nociceptive afferent phenotyping reveals that TRPA1 promotes cold pain via neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor TRPM8.

Aug 24, 2020

The proper detection and behavioral response to painfully cold temperatures is critical for avoiding potentially harmful tissue damage. Cold allodynia and hyperalgesia, pain associated with innocuous ...

Machine learning-based automated classification of headache disorders using patient-reported questionnaires.

Aug 24, 2020

Classification of headache disorders is dependent on a subjective self-report from patients and its interpretation by physicians. We aimed to apply objective data-driven machine learning approaches to...

A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine-A Hypothetical Review.

Aug 24, 2020

Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels ...

MRI in migraineurs: are there abnormalities in the area where the myofascial trigger points are palpable and in volume measurements?

Aug 24, 2020

Patients with migraine may present a higher quantity of myofascial trigger points (MTrP) and alterations in the cervical muscles when compared to non-migraineurs. The magnetic resonance imaging (MRI) ...

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