Aug 20, 2020

MicroRNAs (miRNAs) are single-strand endogenous and non-coding RNA molecules with a length of about 22 nucleotides, which regulate genes expression, through modulating the translation and stability of...

Aug 19, 2020

“There has been very little practical guidance on how to consistently implement reductions in prescribed doses, how to safely taper opioids after surgery, and how to personalize opioid prescribing t...

Aug 17, 2020

Patients hospitalised with COVID-19 have increased morbidity and mortality, which requires extensive involvement of specialist Hospital Palliative Care Teams. Evaluating the response to the surge in d...

Aug 17, 2020

Osseous-associated cervical spondylomyelopathy (OA-CSM) is a complex disorder with limited long-term survival. The longitudinal progression is currently unknown.To describe changes on magnetic resonan...

Aug 17, 2020

Interstitial lung disease (ILD) accounts for the major cause of morbidity and mortality in rheumatoid arthritis (RA). However, little is known of the pathogenesis, diagnosis and treatment of RA-associ...

Aug 17, 2020

A vaccine against coronavirus disease 2019 (COVID-19) is urgently needed.To evaluate the safety and immunogenicity of an investigational inactivated whole-virus COVID-19 vaccine in China.In the phase ...

Aug 17, 2020

To determine the impact of a drug deactivation system to post-surgical patients on the rate of opioid prescription disposal.Two hundred post-operative patients discharged after inpatient surgery at a ...

Aug 17, 2020

Post-traumatic headache (PTH) is a disabling headache disorder and the most common sequela of mild traumatic brain injury. The pathophysiology of PTH is poorly understood and there is limited availabl...

Aug 17, 2020

For future experimental studies or the development of targeted pharmaceutical agents, a deeper insight into the pathophysiology of migraine is of utmost interest. Reliable methods to trigger migraine ...

Aug 17, 2020

We aimed to systematically assess the effectiveness and tolerability of erenumab in a clinical setting, specifically a tertiary headache center.This was a retrospective cohort study at the John Graham...

Aug 17, 2020

The locomotor networks in the spinal cord coordinate muscle contractions and govern limb movements, ensuring postural body stability and smooth locomotion at different speeds. Dissecting the organiza...

Aug 17, 2020

Increased cross-sectional area (CSA) of sural nerve, documented by ultrasound (US), has been revealed in small fibers neuropathy, condition present in about half of patients with fibromyalgia (FM). Th...

Aug 17, 2020

To establish optimal cut-off values for the scores of the revised Fibromyalgia Impact Questionnaire (FIQR), the modified Fibromialgia Assessment Scale (FAS 2019mod), and the Polysymptomatic Distress S...

Aug 17, 2020

Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation. C...

Aug 17, 2020

Juvenile idiopathic arthritis (JIA) is a group of inflammatory conditions of unknown etiology whose incidence is sex dependent. Although several studies have attempted to identify JIA-related gene sig...

Aug 17, 2020

Chronic non-cancer pain, a disabling and distressing condition, is common in adults. It is a global public health problem and economic burden on health and social care systems and on people with chron...

Aug 13, 2020

Maternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Human studies show the deleterious impact of prenatal i...

Aug 13, 2020

In patients with spinal muscular atrophy (SMA), functional disease scores are frequently used to evaluate the course of the disease and the efficacy of treatment. The aim of our study was to propose m...

Aug 13, 2020

Chronic diseases are a major cause of mortality worldwide and despite the recent development in treatment modalities, synthetic drugs have continued to show toxic side effects and development of chemo...

Aug 13, 2020

The chronification of pain can be attributed to changes in membrane receptors and channels underlying neuronal plasticity and signal transduction largely within nociceptive neurons that initiate and m...