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Pain General

Thienorphine induces antinociception without dependence through activation of κ- and δ-, and partial activation of μ- opioid receptor.

Sep 03, 2020

Thienorphine hydrochloride is a new anti-relapse drug for opioid abusers that is currently in phase II clinical trial. In the present study, the antinociception, dependence, and signal transduction in...

Review of addiction risk potential associated with adolescent opioid use.

Sep 03, 2020

Adolescence is a critical period of development with robust behavioral, morphological, hormonal, and neurochemical changes including changes in brain regions implicated in the reinforcing effects of d...

Postoperative Opioid Utilization Associated with Revision Risk Following Primary Shoulder Arthroplasty.

Sep 03, 2020

With a substantial increase in utilization of primary shoulder arthroplasty, it is important to understand risk factors that may signal early failure and need for revision. Recent studies have reporte...

Predicting the outcome of the greater occipital nerve block - an observational study on migraine patients with and without musculoskeletal cervical impairment.

Sep 03, 2020

The importance of neck pain and the trigeminocervical complex in migraine is of high pathophysiological interest since a block to the greater occipital nerve is more effective for some primary headach...

Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study.

Sep 03, 2020

Posttraumatic headache is difficult to define and there is debate about the specificity of the 7-day headache onset criterion in the current definition. There is limited evidence available to guide de...

Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology.

Sep 03, 2020

Migraine is a common and debilitating headache disorder. Although its pathogenesis remains elusive, abnormal trigeminal and central nervous system activity is likely to play an important role. Transie...

Significant Impact of the Ketogenic Diet on Low-Density Lipoprotein Cholesterol Levels.

Sep 03, 2020

It is well known, based on the previous research, that a ketogenic diet leads to an improvement in the lipid profile and decreases cardiovascular risk factors such as hypertension. However, recent stu...

Perceived validation and criticism in pain: development of a new measure in chronic pain.

Sep 03, 2020

Research suggests that the way others react to a pain flare-up impacts on psychological and pain-related symptoms in chronic pain (CP). Experiencing validation from others is associated with less nega...

The 4 U's Rule of Fibromyalgia: A Proposed Model for Fatigue in a Sample of Women with Fibromyalgia: A Qualitative Study.

Sep 03, 2020

Although fatigue usually goes unnoticed, it is a symptom that poses great challenges to patients with fibromyalgia and is a strong limitation. The aim of this study is to identify and describe the var...

Lateral lumbar interbody fusion in revision surgery for restenosis after posterior decompression.

Sep 03, 2020

The purpose of this study was to compare the clinical results of revision interbody fusion surgery between lateral lumbar interbody fusion (LLIF) and posterior lumbar interbody fusion (PLIF) or transf...

Virtual reality approaches to pain: toward a state of the science.

Sep 03, 2020

This brief review provides a summary of existing research on virtual reality (VR) applications to pain. We distinguish three categories of studies - VR applications to clinical acute pain, chronic pai...

Relationship of prosthesis ownership and phantom limb pain: results of a survey in 2,383 limb amputees.

Sep 03, 2020

Phantom limb pain (PLP) accounts for a significant reduction in quality of life and is difficult to treat. Prosthesis use has been shown to negatively co-vary with PLP. Recent research on body percept...

No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy.

Sep 03, 2020

The pathophysiology of pain in neuropathy is complex and may be linked to sensory phenotypes. Quantitative sensory testing, a standardized method to evaluate sensory profiles in response to defined st...

Minimally invasive lateral corpectomy for thoracolumbar traumatic burst fractures.

Sep 03, 2020

The need for anterior column reconstruction after thoracolumbar burst fractures remains controversial. Here, the authors present their experience with minimally invasive lateral thoracolumbar corpecto...

PEEK versus titanium cages in lateral lumbar interbody fusion: a comparative analysis of subsidence.

Sep 03, 2020

The authors have provided a review of radiographic subsidence after lateral lumbar interbody fusion (LLIF) as a comparative analysis between titanium and polyetheretherketone (PEEK) cages. Many author...

Total glucosides of paeony for the treatment of rheumatoid arthritis: A methodological and reporting quality evaluation of systematic reviews and meta-analyses.

Sep 03, 2020

To assess the methodological, reporting and evidence quality of systematic reviews and meta-analyses of total glucosides of paeony (TGP) for rheumatoid arthritis (RA).We comprehensively searched the l...

Mechanism of miRNA-based Aconitum leucostomum Worosch. Monomer inhibition of bone marrow-derived dendritic cell maturation.

Sep 03, 2020

Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucos...

Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-κB/SIRT1/AMPK signaling pathways.

Sep 03, 2020

Safflower yellow (SY) is the main active ingredient of safflower, with various pharmacological effects such as anticoagulating, antioxidant, and anti-arthritis effects.To investigate the anti-inflamma...

Vitamin K2, Arterial Stiffness, & Migraine

Sep 01, 2020

With migraine as the fifth highest cause of years lost due to disability according to the WHO, approximately 38% of patients with migraine requiring preventative therapy but only 3% to 13% using it, a...

Visualization of electrical activity in the cervical spinal cord and nerve roots after ulnar nerve stimulation using magnetospinography.

Aug 31, 2020

To establish a method for magnetospinography (MSG) measurement after ulnar nerve stimulation and to clarify its characteristics.Using a 132-channel magnetoneurography system with a superconducting qua...

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