Advertisement

Opioids

Association of opioid misuse with anxiety and depression: A systematic review of the literature.

Feb 01, 2021

The opioid epidemic is a public health problem associated with a host of negative outcomes. Although clinicians recognize covariation between opioid misuse with anxiety and depressive symptoms and dis...

Anxiety sensitivity and substance use: Differential levels across individuals primarily using opioids, cannabis, or stimulants.

Jan 28, 2021

The purpose of the current study was to compare levels of anxiety sensitivity (AS) across a treatment-seeking sample of individuals primarily using opioids, stimulants, or cannabis. Consistent with th...

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...

Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland.

Jan 28, 2021

The paper describes the first three deaths reported in Europe involved in isotonitazene consumption, a potent benzimidazole derivate opioid consumed in the recreational drug scene. Isotonitazene powde...

Peripheral nerve injury promotes morphine-seeking behavior in rats during extinction.

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...

Death due to consumption of ibogaine: case report.

Jan 14, 2021

Ibogaine is a psychotropic indole alkaloid extracted from the roots of the Tabernanthe iboga shrub from the Apocynaceae family. Depending on the taken dose, it can lead to stimulant effects, euphoria,...

Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers.

Jan 14, 2021

Maternal opioid use in pregnancy has increased dramatically. Knowledge about children's longer-term emotional and behavioral development after prenatal opioid exposure is scarce. A regional sample of ...

Comparing actual and forecasted numbers of unique patients dispensed select medications for opioid use disorder, opioid overdose reversal, and mental health, during the COVID-19 pandemic, United States, January 2019 to May 2020.

Jan 11, 2021

COVID-19 community mitigation measures (e.g., stay-at-home orders) may worsen mental health and substance use-related harms such as opioid use disorder and overdose and limit access to medications for...

Prescription Opioid Use and Laboratory Value Derangements: A Cross-Sectional Analysis of NHANES Data.

Jan 07, 2021

The use of opioids for the treatment of pain is a risk versus benefit analysis and metabolic disease is an often overlooked variable in the equation and may lead to increased risk of comorbidities of ...

Novel curcumin analog (Cis-Trans Curcumin) as ligand to adenosine receptors A and A: potential for therapeutics.

Jan 07, 2021

All four of the adenosine receptor (AR) subtypes mediate pain and have been targeted by pharmacologists to generate new therapeutics for chronic pain. The vanilloid phytochemicals, which include curcu...

Prevalence of childhood maltreatment among people with opioid use disorder: A systematic review and meta-analysis.

Jan 07, 2021

Experience of childhood maltreatment (CM) is a risk factor for opioid use disorder (OUD). CM is also associated with comorbid mental disorders and poor treatment outcomes among people with OUD. To our...

Efficacy and Safety Profile of Rectus Sheath Block in Adult Laparoscopic Surgery: A Meta-analysis.

Jan 04, 2021

Rectus sheath block (RSB) has been increasingly used for pain management after laparoscopic procedures but with a conflicting data on its analgesic efficacy. We conducted a systematic review and meta-...

Analyzing the Effects of Stimulant Abuse in Patients With Burns

Dec 25, 2020

Illicit drug use—including use of stimulants like methamphetamine, amphetamines, and cocaine—continues to be a growing problem throughout the United States. Research has shown that the misuse of i...

An alternative analysis of illicit opioid use during treatment in a randomized trial of extended-release naltrexone versus buprenorphine-naloxone: A per-protocol and completers analysis.

Dec 24, 2020

The distinct pharmacological properties and clinical uses of extended-release naltrexone (XR-NTX) and sublingual buprenorphine-naloxone (BUP-NX) present challenges in analyzing patient outcomes.We con...

Short communication: Systematic review on effectiveness of micro-induction approaches to buprenorphine initiation.

Dec 24, 2020

Micro-induction is a novel buprenorphine induction approach that seeks to avoid withdrawal and minimize precipitated withdrawal, both barriers to standard inductions. We aimed to synthesize evidence o...

Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry.

Dec 21, 2020

New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work w...

Unilateral transcranial photobiomodulation for opioid addiction in a clinical practice: A clinical overview and case series.

Dec 21, 2020

Opioid Use Disorders (OUD) cause great disfunction and pain to individuals, families, and societies. There are few good treatments. This paper presents a novel, easily applied, painless, therapy that ...

Implementing harm reduction in non-urban communities affected by opioids and polysubstance use: A qualitative study exploring challenges and mitigating strategies.

Dec 21, 2020

Harm reduction services, which typically provide overdose education and prevention with distribution of naloxone and other supplies related to safer drug use, help reduce opioid-related overdose and i...

Opioid overdose in the age of fentanyl: Risk factor differences among subpopulations of overdose survivors.

Dec 17, 2020

Although fentanyl is the drug most frequently implicated in overdose deaths, the association between overdose risk and attitudes and behaviors surrounding fentanyl in opioid-using communities has rema...

Outpatient prescribing of opioids to adults diagnosed with mental disorders in the United States.

Dec 14, 2020

Adults with mood and anxiety disorders have an increased likelihood of being prescribed opioids. The influence of other mental disorders, such as psychotic and attention disorders, on opioid prescribi...