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Alcohol Misuse Linked to Poorer Treatment Response in Psoriasis

Oct 26, 2021

“Treatment effectiveness of conventional oral therapies, and of the newer biologic treatments, for moderate-to-severe psoriasis is much lower in real-world clinical practice than in clinical trials,...

"I Know It Is Going to Ruin Their Life:" Fortune-Telling, Agency, and Harm Reduction in Narratives Concerning Injection Initiation Assistance.

Aug 05, 2021

Considering most people who inject drugs (PWID) received help with the first injection, understanding the perspective of potential 'initiators' is a priority to inform harm reduction interventions. Th...

A peripheral antinociceptive effects of a bifunctional μ and δ opioid receptor ligand in rat model of inflammatory bladder pain.

Jul 15, 2021

There is a need to develop a novel analgesic for pain associated with interstitial cystitis/painful bladder syndrome (IC/PBS). The use of the conventional μ-opioid receptor agonists to manage IC/PBS ...

Sex differences in neuroimmune and glial mechanisms of pain.

Jul 15, 2021

Pain is the primary motivation for seeking medical care. Although pain may subside as inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain state can occur ...

CME/CE: A Closer Look at the Association of Alcohol Intake With Hypertension in Type 2 Diabetes

Apr 21, 2021

This course discusses a study that explored the relationship between various levels of alcohol consumption and the risk of hypertension in patients with diabetes. ...

CDC's Efforts to Quantify Prescription Opioid Overdose Deaths Fall Short.

Mar 25, 2021

In a 2018 report titled, Quantifying the Epidemic of Prescription Opioid Overdose Deaths, four senior analysts of the Centers for Disease Control and Prevention (CDC), including the head of the Epidem...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States.

Feb 25, 2021

The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts o...

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

Feb 22, 2021

Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4...

Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins.

Feb 22, 2021

The major problems of morphine use in the clinic are its tolerance and dependence. This study aimed to investigate the effect of suvorexant, a dual orexin receptor antagonist, on morphine-induced depe...

Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.

Feb 22, 2021

In recent years, a number of emergency department (ED)-based interventions have been developed to provide supports and/or treatment linkage for people who use opioids. However, there is limited resear...

Hepatocellular Carcinoma: The Alcohol Pathway for the 4th Leading Cancer-Related Cause of Death

Feb 18, 2021

Hepatocellular carcinoma (HCC) is the fourth most prevalent cause of cancer-related death worldwide, and incidence in the US has tripled in the last 4 decades. Excessive alcohol consumption is one the...

Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care.

Feb 18, 2021

Acute low back pain (LBP) is highly prevalent, with a presumed favorable prognosis; however, once chronic, LBP becomes a disabling and expensive condition. Acute to chronic LBP transition rates vary w...

Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.

Feb 18, 2021

Prenatal opioids exposure negatively affects the neurobehavioral abilities of children born from dependence dams. Adolescent housing conditions can buffer the detrimental impacts of early life experie...

Intermittent REM sleep deprivation attenuates the development of morphine tolerance and dependence in male rats.

Feb 18, 2021

Opioid agonists are used in clinic for pain management, however this application is challenged by development of tolerance and dependence following prolonged exposure. Various approaches have been sug...

Hippocampal TNF-α Signaling Mediates Heroin Withdrawal-Enhanced Fear Learning and Withdrawal-Induced Weight Loss.

Feb 15, 2021

There is significant comorbidity of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical populations. However, the neurobiological mechanisms underlying the relationship bet...

PAIN CATASTROPHIZING, OPIOID MISUSE, OPIOID USE, AND OPIOID DOSE IN PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN: A SYSTEMATIC REVIEW.

Feb 15, 2021

The objective of this study was to analyze the cross-sectional and longitudinal association between pain catastrophizing and opioid misuse, opioid use, and opioid dose in people with chronic musculosk...

Carfentanil - from an animal anesthetic to a deadly illicit drug.

Feb 15, 2021

The use of novel synthetic opioids as recreational drugs has become a public health concern as they are implicated in numerous fatal intoxications across the world. Synthetic opioids have played a maj...

Discharge Opioid Prescription Patterns after Kidney Cancer Surgery.

Feb 11, 2021

To describe opioid prescribing patterns for patients undergoing kidney cancer surgery and evaluate associations with medical resource utilization in the postoperative setting.Linked Surveillance, Epid...