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Bipolar Disorder

Schema Therapy for Patients with Bipolar Disorder: Theoretical Framework and Application.

Jan 17, 2022

Bipolar disorder (BD) is a severe mood disorder characterized by episodes of depression and hypomania or mania. Despite its primarily biological roots, the onset and course of the disorder have also b...

Neurocysticercosis presenting as bipolar disorder: a case report.

Jan 17, 2022

Neurocysticercosis is the most common neuro-parasitosis caused by the larval stage of . The most common manifestations include seizures and hydrocephalus. Psychiatric abnormalities are relatively rare...

Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance - Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase.

Jan 10, 2022

While the favorable effect of adjuvant clonidine in the treatment of acute mania has been observed already about 40 years ago, this line of treatment has not been further investigated. Here, we resume...

The position statement of the Working Group of the Polish Psychiatric Association on the use of D2/D3 dopamine receptor partial agonists in the treatment of mental disorders.

Jan 10, 2022

Aripiprazole, cariprazine and brexpiprazole are antipsychotic drugs (APD) whose action is associated with partial agonism at the dopamine D2/D3 receptors. They are increasingly more widely used in cli...

Influence of Prenatal Methamphetamine Abuse on the Brain.

Jan 03, 2022

Methamphetamine (MA), a psychostimulant, has become a serious problem in recent years. It is one of the most widely abused psychostimulants in the world. In the Czech Republic, ecstasy is the most com...

Patterns and Predictors of Off-Label Drug Prescribing in Psychiatric Practice: A Qualitative Study.

Dec 27, 2021

Off-label drug prescribing (OLDP) must be based on strong scientific evidence to make sure that patients get the optimum therapeutic outcomes. Adherence to the prerequisites is determined by the physi...

Post-Traumatic Stress Disorder Secondary to Manic Episodes with Hypersexuality in Bipolar Disorder: A Case Study of Forensic Psychotherapy.

Dec 20, 2021

Post-traumatic stress disorder (PTSD) can arise as a secondary condition to a primary bipolar disorder, an aspect which may be overlooked by clinicians and thus may contribute to the exacerbation of t...

Imipramine induces hyperactivity in rats pretreated with ouabain: Implications to the mania switch induced by antidepressants.

Dec 20, 2021

Bipolar disorder (BD) is a psychiatric disorder with complex therapy, besides the treatment with antidepressants induce a mania switch.Investigate the effect of the administration of imipramine (IMI) ...

Behavioural and Self-Reported Data Collected from Smartphones in the Assessment of Depressive and Manic Symptoms for Bipolar Disorder Patients: Prospective Observational Study.

Dec 13, 2021

Smartphones allow for real-time monitoring of patients' behavioural activities in a naturalistic setting. These data are suggested as markers of mental state in bipolar disorder (BD).We assess the rel...

Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial.

Dec 13, 2021

To examine the antidepressant efficacy and response predictors of R-DLPFC-LF rTMS for antidepressant-nonresponding BD.We conducted a single-blind randomized sham-controlled trial for 54 (28 sham, 26 a...

Correction of depression-associated circadian rhythm abnormalities is associated with lithium-response in bipolar disorder.

Nov 29, 2021

Bipolar disorder (BD) is characterized by episodes of depression and mania and disrupted circadian rhythms. Lithium is an effective therapy for BD, but only 30-40% of patients are fully responsive. Pr...

Bipolar Disorder and Comorbid Use of Illicit Substances.

Nov 29, 2021

Substance use disorders (SUD) are highly prevalent in bipolar disorder (BD) and significantly affect clinical outcomes. Incidence and management of illicit drug use differ from alcohol use disorders, ...

Cariprazine-induced mania: a case-series report.

Nov 22, 2021

Bipolar depression is the most prevalent phase of bipolar disorder (BD). There is a risk of inducing treatment-emergent affective switches (TEAS) with antidepressants (ADs). Hence, clinical guidelines...

Does metabolic syndrome or its component factors alter the course of bipolar disorder? A systematic review.

Nov 22, 2021

Metabolic syndrome (MetS) and its component factors, obesity, hypertension, dyslipidaemia and insulin resistance, have shown a bidirectional relationship with the prevalence and severity of bipolar di...

Neural autoantibodies in delirium.

Nov 15, 2021

Delirium in hospitalized and intensive care unit patients is an emerging condition due to its rapid-onset requiring fast action to mitigate a worse clinical outcome. Although several causes and condit...

What not to use in bipolar disorders: a systematic review of non-recommended treatments in clinical practice guidelines.

Nov 15, 2021

Clinical practice guidelines (CPG) are an important tool for implementation of evidence-based clinical care. Despite clinical trials showing lack of efficacy of some agents in bipolar disorder (BD), t...

Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential.

Nov 08, 2021

Dextromethorphan (DM) abuse produces mania-like symptoms in humans. ERK/Akt signaling activation involved in manic potential can be attenuated by the inhibition of ouabain-like cardiac steroids. In th...

Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.

Nov 01, 2021

Because of the involvement of the brain in the pathophysiology of psychiatric disorders, obtaining information on the biochemical features that directly contribute to symptoms is challenging. The pres...

Selective serotonin reuptake inhibitors and manic switch: A pharmacovigilance and pharmacodynamical study.

Nov 01, 2021

There is still no approved mechanism of manic switch in bipolar disorder, yet many selective serotonin reuptake inhibitors were accused for this important adverse event. Therefore, we aimed to investi...

Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation.

Oct 25, 2021

Emotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fro...