High-quality genomes reveal new differences between the great apes.
Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract
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Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract
Read MoreJul 29, 2018
Nature 2018 07 18() doi 10.1038/s41586-018-0342-5 Abstract Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours,...
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Bone & joint research 6(7) 399-404 doi 10.1302/2046-3758.67.BJR.2016-0255.R1 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical...
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Science translational medicine 10(450) pii 10.1126/scitranslmed.aar3342 Abstract Combination anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed cell death protein 1 (PD-1) therapy promotes antitumor immunity and...
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Nature methods 2018 07 16() doi 10.1038/s41592-018-0048-5 Abstract The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its...
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Nature communications 2018 06 309(1) 2447 doi 10.1038/s41467-018-04907-0 Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for...
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eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...
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Genes & development 2018 06 2732(13-14) 929-943 doi 10.1101/gad.313932.118 Abstract While a mutation in is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning...
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The New England journal of medicine 2018 06 25() doi 10.1056/NEJMoa1805233 Abstract Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing...
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The New England journal of medicine 2018 06 26() doi 10.1056/NEJMoa1716435 Abstract Background The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently...
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Cell 2018 06 13() pii 10.1016/j.cell.2018.05.047 Abstract The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the...
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The Journal of clinical investigation 2018 06 26() doi 10.1172/JCI96393 Abstract Dormant or slow-cycling tumour cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery...
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Cell 2018 06 12() pii 10.1016/j.cell.2018.05.039 Abstract Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes...
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Nature communications 2018 06 199(1) 2404 doi 10.1038/s41467-018-04495-z Abstract A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive...
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The New England journal of medicine 2018 06 13378(25) e34 doi 10.1056/NEJMoa1800389 Abstract BACKGROUND Observational cohort studies and a secondary prevention trial have shown inverse associations between adherence to the...
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The New England journal of medicine 2018 06 13378(25) 2441-2442 doi 10.1056/NEJMc1806491 Abstract
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Cell 2018 06 09() pii 10.1016/j.cell.2018.05.057 Abstract The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown. We present a single-cell transcriptome atlas...
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Sports (Basel, Switzerland) 2018 01 096(1) pii 10.3390/sports6010001 Abstract Adopting low carbohydrate, ketogenic diets remains a controversial issue for individuals who resistance train given that this form of dieting has been...
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eLife 2018 06 127() doi 10.7554/eLife.33246 Abstract Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises...
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Proceedings of the National Academy of Sciences of the United States of America 2018 06 11115(26) 6822-6827 doi 10.1073/pnas.1806308115 Abstract Novel reassortant avian influenza H7N9 virus and pandemic 2009 H1N1 (H1N1pdm) virus...
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