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Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies.

Feb 17, 2020

Pandemics caused by influenza A virus (IAV) are responsible for the deaths of millions of humans around the world. One of these pandemics occurred in Mexico in 2009. Despite the impact of IAV on human...

Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults.

Feb 17, 2020

The seasonal influenza vaccine is an important public health tool but is only effective in a subset of individuals. The identification of molecular signatures provides a mechanism to understand the dr...

A Requirement for Argonaute 4 in Mammalian Antiviral Defense

Feb 13, 2020

While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro ...

FluPhenotype - a one-stop platform for early warnings of the influenza A virus.

Feb 13, 2020

Newly emerging influenza viruses keep challenging global public health. In order to evaluate the potential risk of the viruses, it is critical to rapidly determine the phenotypes of the viruses, inclu...

Respiratory syncytial and influenza virus detecting rapid tests in children younger than 5 years of age in Armenia.

Feb 13, 2020

Acute respiratory infections (ARIs) are major causes of morbidity in early childhood. They are mainly caused by viruses, including influenza (INF) and respiratory syncytial viruses (RSV). We aimed to ...

Epidemic features of seasonal influenza transmission among eight different climate zones in Gansu, China.

Feb 13, 2020

Seasonal influenza remains epidemic globally with a substantial health burden. Understanding the transmission patterns and epidemic features of influenza may facilitate the improvement of preventive a...

Effectiveness, immunogenicity, and safety of influenza vaccines with MF59 adjuvant in healthy people of different age groups: A systematic review and meta-analysis.

Feb 13, 2020

Influenza is a severe disease burden among all age groups. This study aimed to review the efficacy of inactivated influenza vaccines with MF59 adjuvant and non-adjuvanted inactivated influenza vaccine...

Health effects associated with short-term exposure to hydrogen sulfide from geothermal power plants: a case-crossover study in the geothermal areas in Tuscany.

Feb 10, 2020

Thirty-four geothermal power plants for the production of electricity are currently active in the geothermal areas in Tuscany. The present study aimed to investigate the association between short-term...

RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness.

Feb 10, 2020

Decreased tumor necrosis factor (TNF)-α production in whole blood following ex vivo lipopolysaccharide (LPS) stimulation indicates suppression of the toll-like receptor (TLR)4 pathway. This is associ...

Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx.

Feb 10, 2020

Nasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality durin...

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults.

Feb 10, 2020

Seasonal influenza vaccination with a standard trivalent influenza vaccine (TIV) induces a modest, and cross-reactive, Fc functional antibody response in older adults. Recent improvements to influenza...

Enhanced influenza vaccination among healthcare personnel prevents cases despite community burden.

Feb 10, 2020

Influenza vaccination for healthcare personnel is not obligatory in Mexico, and compliance relies on promotion and persuasion. The objective of this study was to determine the impact of influenza vacc...

Effectiveness of Trivalent and Quadrivalent Inactivated Vaccines against Influenza B in the United States, 2011-2012 to 2016-2017.

Feb 04, 2020

Since 2013, quadrivalent influenza vaccines containing two B viruses gradually replaced trivalent vaccines in the United States. We compared vaccine effectiveness of quadrivalent to trivalent inactiva...

Strain specificities in influence of ageing on germinal centre reaction to inactivated influenza virus antigens in mice: Sex-based differences.

Feb 04, 2020

Considering variability in vaccine responsiveness across human populations, in respect to magnitude and quality, and importance of vaccines in the elderly, the influence of recipient genetic backgroun...

Adaption and Parallel Evolution of Human-Isolated H5 Avian Influenza Viruses

Feb 04, 2020

Avian-to-human transmission of highly pathogenic avian influenza viruses (HPAIV) and their subsequent adaptation to humans are of great concern to public health. Surveillance and early warning of AIVs...

Bronchiectasis in rheumatoid arthritis. A clinical appraisial.

Feb 04, 2020

Bronchiectasis is defined as irreversibly damaged and dilated bronchi and is one of the most common pulmonary manifestations in patients with rheumatoid arthritis (RA). The model of RA-associated auto...

Demographic, clinical, and virological characteristics of patients with a laboratory-confirmed diagnosis of influenza during three consecutive seasons, 2015/2016-2017/18, in the Islamic Republic of Iran.

Feb 04, 2020

There are minimal data on the differences in demographics, clinical presentations and outcomes for patients with different types and sub-types of influenza in the Middle East.To use population-based d...

Pneumonia in Bhutanese children: what we know, and what we need to know.

Jan 31, 2020

Pneumonia is the single largest cause of death in under-five children worldwide. We conducted a systematic review to identify the knowledge gaps around childhood pneumonia in Bhutan.We searched PubMed...

Hemagglutinin-Specific Non-neutralizing Antibody Is Essential for Protection Provided by Inactivated and Viral-Vectored H7N9 Avian Influenza Vaccines in Chickens.

Jan 31, 2020

Hemagglutination inhibition (HI) and virus neutralization antibody (nAb) do not always correlate with the protection of H7 avian influenza vaccines in mammals and humans. The contribution of different...

Tempel: Time-series Mutation Prediction of Influenza A Viruses via Attention-based Recurrent Neural Networks.

Jan 31, 2020

Influenza viruses are persistently threatening public health, causing annual epidemics, and sporadic pandemics. The evolution of influenza viruses remains to be the main obstacle in the effectiveness ...