The following is the summary of “Correlation between serum cystatin C level and renal microvascular perfusion assessed by contrast-enhanced ultrasound in patients with diabetic kidney disease” published in the October 2022 issue of Renal failure by Zhao, et al.
Patients with diabetic kidney disease were studied to determine if there was a correlation between blood cystatin C (CysC) levels and renal microvascular perfusion (DKD). The study included 57 patients with elevated CysC levels and 45 participants with normal CysC levels. In addition to collecting demographic information, researchers also gathered clinical features and laboratory examination data. Sequential contrast-enhanced ultrasonography (CEUS) of the kidneys was carried out.
Correlations between CysC and CEUS parameters were studied after the time-intensity curve (TIC) and related quantitative data of the kidneys were acquired using CEUS. Compared to the normal CysC group, the high CysC group had significantly lower wash-in area under the curve (WiAUC), wash-out area under the curve (WoAUC), and wash-in and wash-out area under the curve (WiWoAUC). In the normal CysC group, patients with Stage III chronic kidney disease (CKD) had higher area under the curves (AUCs) than those with Stage I–II CKD (P<0.05). In the high CysC group, patients with Stage IV–V CKD had lower wash-in AUC compared to patients with Stage I–II CKD (P=0.023).
The renal cortex microvascular perfusion parameters AUCs were positively correlated with the estimated glomerular filtration rate (GFR) (r=0.280, 0.222, and 0.243), and CysC was inversely correlated with AUCs (r= −0.299, −0.251, and −0.273). AUCs may be good markers of decreased Glomerular filtration rate(GFR) in DKD patients with elevated CysC, while CEUS characteristics showed changes in renal microvascular perfusion in individuals with DKD.
Source: tandfonline.com/doi/full/10.1080/0886022X.2022.2134026