The following is a summary of “Incidence and clinical factors associated with ulceration in infantile hemangiomas,” published in the FEBRUARY 2023 issue of Dermatology by Faith, et al.

Infantile hemangiomas (IHs) are commonly associated with ulceration, which was estimated to occur in 15%-30% of the referral population prior to the use of β-blockers. However, the incidence and factors associated with ulceration have not been studied systematically since β-blocker therapy became widespread. 

For a study at tertiary referral centers, researchers sought to examine the incidence and clinical predictors for ulceration in IHs.

The results of the study showed that the incidence of ulceration in IHs has decreased to 11.4% with the use of β-blockers. Clinical factors that were found to be associated with ulceration included partial segmental morphology, location in the diaper area, and size greater than 5 cm. Additionally, Black patients were observed to have a higher risk of ulceration, which suggests delayed diagnosis and referral to specialty care may be barriers to care.

The study had some limitations, such as the retrospective design and the fact that it was conducted at tertiary referral centers. Nonetheless, the study showed that the incidence of ulceration in IHs has decreased with the use of β-blockers. However, ulceration continues to be a relatively frequent complication of IH, and clinical factors associated with ulceration should be considered when managing patients with IHs.

Reference: jaad.org/article/S0190-9622(22)02973-5/fulltext