The following is a summary of “Follow-Up of Patients After Total Pancreatectomy and Islet Cell Autotransplantation at Off-Site Islet Isolation Facility,” published in the June 2023 issue of Endocrinology & Metabolism by Lad, et al.
For a study, researchers sought to evaluate the efficacy of total pancreatectomy with islet autotransplantation (TPIAT) in patients with chronic pancreatitis (CP) by conducting a follow-up of up to 12 years.
A total of 44 patients (median age: 46.0 years; range: 20-78 years) who underwent TPIAT for CP were included in the study. Data on patient demographics, mixed meal tolerance test measures, glycosylated hemoglobin, insulin requirements, and homeostatic model assessment for insulin resistance values were collected before the surgery and at the most recent follow-up assessment.
At a median follow-up time of 845.5 days (range: 195-4,470 days), 8 patients achieved insulin independence, while 36 patients remained insulin dependent. The most significant predictor of insulin independence was the islet yield per kilogram. Homeostatic model assessment for insulin resistance values was comparable between the insulin-independent and insulin-dependent groups.
The long-term follow-up data indicated that islet autotransplantation (IAT) as a part of TPIAT can effectively reduce insulin requirements and improve postoperative glycemic control in patients with chronic pancreatitis.
Source: academic.oup.com/jcem/article-abstract/108/6/1425/6889603?redirectedFrom=fulltext