The following is a summary of “Acute Liver Failure in Dengue: A Common but Overlooked Entity in Pediatric Patients in Tropical Countries,” published in the February 2023 issue of Gastroenterology and Nutrition by Dogra, et al.
For a study, researchers sought to uncover prognostic variables linked to mortality, assess the incidence of acute liver failure (ALF) in dengue infection, and comprehend the demographic and biochemical profiles.
The study was done in the past by observation. To find children who met the requirements for pediatric ALF, they examined the data of all pediatric dengue patients hospitalized during the previous five years at the hospital. The demographic profile, as well as the radiological and biochemical data, were evaluated. To find prognostic indicators, these patients’ outcomes and mortality data were examined.
Thirty kids were found to have dengue illness during the ALF study period, which represented 29.1% (30 of 103) of all our ALF admissions. During the same time period, 189 children with dengue illness required admission, and 30 of these (15.8%) developed ALF. ALF typically began 5.4 days after the beginning of the fever. Eight patients died, leaving 22 patients (73%) who survived. In individuals who did not survive, high creatinine, low albumin levels, and multisystemic involvement were poor prognostic indicators.
ALF is frequent among severely ill dengue patients who are hospitalized. Dengue infection is responsible for a sizable share of acute liver sufferers in endemic nations. Prognostic indicators for these kids include low blood albumin, excessive creatinine, and multi-organ failure during acute illness. To verify these findings, multicentric prospective studies were required.
Reference: journals.lww.com/jpgn/Abstract/2023/02000/Acute_Liver_Failure_in_Dengue__A_Common_but.7.aspx