The aim is to report the results of radiofrequency ablation (RFA) in patients with symptomatic benign thyroid nodules (SBTN) within our regional Thyroid Network and to evaluate their health-related and thyroid-related quality of life (QoL).
Eligibility criteria for RFA were nodule size between 2.0 cm and 5.0 cm; solid component >20%; benign cytology on two separate cytological assessments and unequivocal symptoms related to mechanical compression. The primary end point of this study was volume reduction at 1 year post ablation. Secondary outcomes were health-related and thyroid related QoL measured by the SF-36 and ThyPRO-39 questionnaire as well as complication rates.
A total of 72 SBTN in 67 patients were included. The median age was 50.0 [IQR: 41.0 – 56.0] years and 91.0% were women. Median volume reduction at 6 weeks, 6 months, 1 year, 2 years, and 3 years were 51.0%, 63.9%, 65.2%, 81.3% and 90.3% respectively. Patients showed significant improvement on the SF-36 physical component scale and the ThyPRO-39 overall QoL-impact scale. An absolute improvement was seen within the ThyPRO-39 goiter and cosmetic complaints. The overall complication rate was 9.0%, of which 4.5% were considered major.
RFA is an effective treatment option for SBTN with significant volume reduction and improvement in health-related and thyroid-related QoL.

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