Real-World Evaluation of Anticoagulant Treatment Patterns in Patients with Atrial Fibrillation: Data from Multicenter ROTA Study.

Mar 20, 2023

Contributors: Umut Kocabaş,Işıl Ergin,Veysel Yavuz,Selda Murat,Ibrahim Özdemir,Ömer Genç,Cihan Altın,Haşim Tüner,Bengisu Keskin Meriç,Ali Çoner,Elif İlkay Yüce,Bedrettin Boyraz,Onur Aslan,Ahmet Dal,Taner Şen,Ersin İbişoğlu,Aslan Erdoğan,Mehmet Özgeyik,Mevlüt Demir,Ziya Gökalp Bilgel,Büşra Güvendi Şengör,Örsan Deniz Urgun,Mustafa Doğduş,Deniz Dilan Naki Tekin,Sinem Çakal,Sercan Çayırlı,Arda Güler,Dilay Karabulut,Onur Dalgıç,Osman Uzman,Bektaş Murat,Şeyda Şahin,Umut Karabulut,Tarık Kıvrak,Muharrem Said Coşgun,Ferhat Özyurtlu,Mehmet Kaplan,Emre Özçalık

Oral anticoagulant therapy is the cornerstone of atrial ﬁbrillation management to prevent stroke and systemic embolism. However, there is limited real-world information regarding stroke and systemic embolism prevention strategies in patients with atrial ﬁbrillation. The aim of the ROTA study is to obtain the real-world data of anticoagulant treatment patterns in patients with atrial ﬁbrillation.
The ROTA study is a prospective, multicenter, and observational study that included 2597 patients with atrial ﬁbrillation. The study population was recruited from 41 cardiology outpatient clinics between January 2021 and May 2021.
The median age of the study population was 72 years (range: 22-98 years) and 57.4% were female. The median CHA2DS2-VASc and HAS-BLED scores were 4 (range: 0-9) and 1 (range: 0-6), respectively. Vitamin K antagonists and direct oral anticoagulants were used in 15.9% and 79.4% of patients, respectively. The mean time in therapeutic range was 52.9% for patients receiving vitamin K antagonists, and 76% of those patients had an inadequate time in therapeutic range with <70%. The most common prescribed direct oral anticoagulants were rivaroxaban (38.1%), apixaban (25.5%), and edoxaban (11.2%). The rate of overuse of vitamin K antagonists and direct oral anticoagulants was high (76.1%) in patients with low stroke risk, and more than one-fourth of patients on direct oral anticoagulant therapy were receiving a reduced dose of direct oral anticoagulants. Among patients who were on direct oral anticoagulant treatment, patients with apixaban treatment were older, had higher CHA2DS2-VASc and HAS-BLED scores, and had lower creatinine clearance than the patients receiving other direct oral anticoagulants.
The ROTA study provides important real-world information about anticoagulant treatment patterns in patients with atrial ﬁbrillation.time in therapeutic range with <70%.

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ABOUT THE CONTRIBUTORS

Umut Kocabaş,Işıl Ergin,Veysel Yavuz,Selda Murat,Ibrahim Özdemir,Ömer Genç,Cihan Altın,Haşim Tüner,Bengisu Keskin Meriç,Ali Çoner,Elif İlkay Yüce,Bedrettin Boyraz,Onur Aslan,Ahmet Dal,Taner Şen,Ersin İbişoğlu,Aslan Erdoğan,Mehmet Özgeyik,Mevlüt Demir,Ziya Gökalp Bilgel,Büşra Güvendi Şengör,Örsan Deniz Urgun,Mustafa Doğduş,Deniz Dilan Naki Tekin,Sinem Çakal,Sercan Çayırlı,Arda Güler,Dilay Karabulut,Onur Dalgıç,Osman Uzman,Bektaş Murat,Şeyda Şahin,Umut Karabulut,Tarık Kıvrak,Muharrem Said Coşgun,Ferhat Özyurtlu,Mehmet Kaplan,Emre Özçalık
Umut Kocabaş

Başkent University Izmir Hospital, Department of Cardiology, Izmir, Türkiye.

Işıl Ergin

Ege University, Faculty of Medicine, Department of Public Health, Izmir, Türkiye.

Veysel Yavuz

Akhisar State Hospital, Department of Cardiology, Manisa, Türkiye.

Selda Murat

Eskişehir Osmangazi University, Faculty of Medicine, Department of Cardiology, Eskişehir, Türkiye.

Ibrahim Özdemir

Manisa City Hospital, Department of Cardiology, Manisa, Türkiye.

Ömer Genç

Ağrı Training and Research Hospital, Department of Cardiology, Ağrı, Türkiye.

Cihan Altın

Izmir University of Economics, Faculty of Medicine, Department of Cardiology, Izmir, Türkiye.

Haşim Tüner

Hakkari State Hospital, Department of Cardiology, Hakkari, Türkiye.

Bengisu Keskin Meriç

Babaeski State Hospital, Department of Cardiology, Kırklareli, Türkiye.

Ali Çoner

Başkent University Alanya Hospital, Department of Cardiology, Antalya, Türkiye.

Elif İlkay Yüce

Fethiye State Hospital, Department of Cardiology, Muğla, Türkiye.

Bedrettin Boyraz

Tatvan State Hospital, Department of Cardiology, Bitlis, Türkiye.

Onur Aslan

Mersin City Hospital, Department of Cardiology, Mersin, Türkiye.

Ahmet Dal

Izmir University of Economics, Faculty of Medicine, Department of Cardiology, Izmir, Türkiye.

Taner Şen

Kütahya Health Sciences University, Faculty of Medicine, Department of Cardiology, Kütahya, Türkiye.

Ersin İbişoğlu

Başakşehir Çam and Sakura City Hospital, Department of Cardiology, Istanbul, Türkiye.

Aslan Erdoğan

Başakşehir Çam and Sakura City Hospital, Department of Cardiology, Istanbul, Türkiye.

Mehmet Özgeyik

Eskişehir City Hospital, Department of Cardiology, Eskişehir, Türkiye.

Mevlüt Demir

Kütahya Health Sciences University, Faculty of Medicine, Department of Cardiology, Kütahya, Türkiye.

Ziya Gökalp Bilgel

Başkent University Adana Hospital, Department of Cardiology, Adana, Türkiye.

Büşra Güvendi Şengör

Maltepe State Hospital, Department of Cardiology, Istanbul, Türkiye.

Örsan Deniz Urgun

Kozan State Hospital, Department of Cardiology, Adana, Türkiye.

Mustafa Doğduş

Uşak University Training and Research Hospital, Department of Cardiology, Uşak, Türkiye.

Deniz Dilan Naki Tekin

Başakşehir Çam and Sakura City Hospital, Department of Cardiology, Istanbul, Türkiye.

Sinem Çakal

Health Sciences University, Haseki Training and Research Hospital, Department of Cardiology, Istanbul, Türkiye.

Sercan Çayırlı

Adnan Menderes University, Faculty of Medicine, Department of Cardiology, Aydın, Türkiye.

Arda Güler

Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Türkiye.

Dilay Karabulut

Istanbul Bakirköy Dr Sadi Konuk Training and Research Hospital, Department of Cardiology, Istanbul, Türkiye.

Onur Dalgıç

Kardiya Medical Center, Department of Cardiology, Izmir, Türkiye.

Osman Uzman

Sarıkamış State Hospital, Department of Cardiology, Kars, Türkiye.

Bektaş Murat

Eskişehir City Hospital, Department of Cardiology, Eskişehir, Türkiye.

Şeyda Şahin

Turhal State Hospital, Department of Cardiology, Tokat, Türkiye.

Umut Karabulut

Istanbul Acıbadem International Hospital, Department of Cardiology, Istanbul, Türkiye.

Tarık Kıvrak

Elazığ Fırat University, Faculty of Medicine, Department of Cardiology, Elazığ, Türkiye.

Muharrem Said Coşgun

Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital, Department of Cardiology, Erzincan, Türkiye.

Ferhat Özyurtlu

Grandmedical Hospital, Department of Cardiology, Manisa, Türkiye.

Mehmet Kaplan

Gaziantep University, Faculty of Medicine, Department of Cardiology, Gaziantep, Türkiye.

Emre Özçalık

Başkent University Izmir Hospital, Department of Cardiology, Izmir, Türkiye.