The following is a summary of “TUBB8 mutations as a cause of oocyte maturation abnormalities: presentation of oocyte and embryo profiles and novel mutations,” published in the November 2023 issue of Obstetrics and Gynecology by Ebru, et al.
What are the developmental traits and oocyte maturation patterns in people with TUBB8 mutations that cause oocyte maturation abnormalities (OMAS)? Is it possible for this group of people to get pregnant? Researchers sought to find this out in a private fertility center from January 2019 to December 2022 as a prospective group study. Whole-exome genetic studies (WES) were carried out to find the types of mutations. About 9 people with TUBB8 mutations and nine without TUBB8 mutations were used as a control group to compare in vitro maturation (IVM).
The patterns of egg maturity and fetal growth were written down. The results of the 18 IVF and IVM cases were looked at. The main results were the embryonic patterns and development dynamics of eggs from women with IVF or IVM compared to those with TUBB8 mutations. 52 of the 89 women who had WES screening (58.4%) had mutations found. Twelve changes in TUBB8 were found in nine women (10.1%) who had OMAS. Seven new variants in TUBB8 were found. Women who had the c.535 G>A TUBB8 mutation got pregnant twice. Women with and without TUBB8 mutations had the same IVF results. There were no changes in the egg, embryo, or pregnancy factors (P>0.05 in all cases).
It was certain that in the future, more TUBB8 variants that stop oocytes or embryos from developing will be found. Biochemical or ectopic pregnancies may happen in some of these women, but as of now, there have been no reports of live births or pregnancies that are still going on.
Source: sciencedirect.com/science/article/abs/pii/S1472648323003577