The following is a summary of “Lower versus higher oxygen targets after resuscitation from out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials,” published in the February 2024 issue of Critical Care by Xu et al.
Researchers started a retrospective study to update the proof of the effects of lower versus higher oxygen targets on outcomes in patients resuscitated from out-of-hospital cardiac arrest (OHCA).
They conducted a review and meta-analysis of randomized controlled trials (RCTs), evaluating lower versus higher oxygen targets among adults revived from OHCA. The key focus was short-term survival (either in-hospital or within 30 days). Subgroup analyses were conducted based on intervention timing.
The results showed 7 RCTs involving 1,454 patients. Short-term survival exhibited no significant difference between the two groups, with a relative risk (RR) of 0.98 (95% CI, 0.86 to 1.11). There were no statistically significant variances in survival at the most extended follow-up (RR, 1.01; 95% CI, 0.91 to 1.14), favorable neurological outcome (RR, 1.00; 95% CI, 0.91 to 1.11), duration of intensive care unit stay (mean difference, −4.94 hours; 95% CI, −14.83 to 4.96 hours), or the risk of re-arrest (RR, 0.68; 95% CI, 0.21 to 2.19). The quality of evidence spanned from moderate to very low.
Investigators concluded that lower versus higher oxygen targets after OHCA do not differ in short-term survival and other clinical outcomes.