LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling...
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1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling...
Read MoreFeb 26, 2022
1. Atezolizumab plus capecitabine + bevacizumab performed marginally better with regards to...
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1. This prospective cohort study demonstrated that, in adult patients with active cancer and a...
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1. Grief measured at 6 months following the patient’s death was significantly lower in relatives...
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1. COVID-19 caused the second-largest infection-related mortality disaster in Switzerland, Sweden,...
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1. Compared to population- and sibling-matched cohorts, women previously diagnosed with cervical...
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1. In this retrospective study, individuals who sought care at a concussion specialty clinic 15-30...
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1. This retrospective cohort study found that, in comparison to the total US population, post-9/11...
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1. A randomized, split-block psychological experiment utilizing clinical vignettes provides...
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1. The median progression-free survival for trametinib was significantly greater than that for...
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1. In a large retrospective study, rates of venous thromboembolism (VTE) in pediatric patients...
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1. Compared with generic oral emtricitabine-tenofovir disoproxil fumarate (F/TDF), long-acting...
Read MoreFeb 15, 2022
1. Compared with generic oral emtricitabine-tenofovir disoproxil fumarate (F/TDF), long-acting...
Read MoreFeb 15, 2022
1. Among symptomatic patients with high low-density lipoprotein cholesterol levels considered high...
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1. In this study, counselors reported that patients would be more likely to access buprenorphine treatment if they had access to greater social resources, such as housing or internet. 2. Counselors also report that increased screening at intake about psychosocial factors would be helpful. Evidence Rating Level: 3 (Average) One of the current national public […]
Read MoreFeb 8, 2022
1. In patients with gout and chronic kidney disease, the initiation of allopurinol was not associated with increased mortality. 2. In patients with gout and chronic kidney disease, dose escalation of allopurinol nor achieving target serum urate levels was associated with increased mortality. Evidence Rating Level: 2 (Good) Study Rundown: Serum urate (SU) lowering medications […]
Read MoreFeb 8, 2022
1. In this cross-sectional study, there was a 57% increase in new-onset Type 1 Diabetes diagnoses in children at a tertiary care hospital during a 12-month period of the COVID-19 pandemic. 2. Incidence of diabetic ketoacidosis on presentation increased from 41% to 50%. Evidence Rating Level: 2 (Good) Study Rundown: Type 1 diabetes (T1D) is […]
Read MoreFeb 8, 2022
1. Patients hospitalized with COVID-19 receiving at least one dose of molnupiravir did not show reduced mortality compared to patients receiving placebo treatment. 2. Molnupiravir was not associated with any dose-limiting side effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Molnupiravir is a small molecule that interferes with the viral genome replication process in RNA […]
Read MoreFeb 8, 2022
1. The use of a neoadjuvant gemcitabine-based chemoradiotherapy before surgery and adjuvant gemcitabine increased the overall survival rate when compared to upfront surgery and adjuvant gemcitabine. 2. Patients in the neoadjuvant chemoradiotherapy groups had more R0 resections than patients receiving upfront surgery and adjuvant gemcitabine. Evidence Rating Level: 1 (Excellent) Study Rundown: Past randomized control […]
Read MoreFeb 8, 2022
1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0 genotype patients. 2. The gene therapy resulted in a total hemoglobin level sufficient for transfusion independence in these patients. Evidence Rating Level: 1 (Excellent) Study Rundown: β-thalassemia is caused by β-globin gene mutations, leading to […]
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