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OB/GYN General

Implementation of a Universal Pregnancy Screening Process for Substance Abuse

Jan 24, 2022

For a study, a standardized universal drug screening approach was implemented in an outpatient prenatal clinic in an urban tertiary care hospital. Researchers implemented universal drug use screening ...

Rates of Vaginal Hysterectomy Before and After the Implementation of a Multi-Tier Intervention

Jan 24, 2022

For a study, researchers wanted to evaluate the efficacy of a multi-tiered strategy to improve vaginal hysterectomy rates. At a single tertiary care medical center, the researchers conducted cohort re...

Counseling for Smoking Cessation Behaviorally During Pregnancy

Jan 24, 2022

For a study, researchers wanted to determine the cost-effectiveness of employing behavioral smoking cessation therapy during pregnancy. Researchers created a decision-analytic model using software to ...

Multiple Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma) with Extradural Involvement in a 7-Year-Old Labrador Retriever.

Jan 24, 2022

A 7-year-old castrated male Labrador retriever was referred for evaluation of progressive hind limb paresis of 4 weeks' duration. On computed tomography and magnetic resonance imaging examination, mas...

Severe Intraoperative Hyperglycemia and Infectious Complications After Elective Brain Neurosurgical Procedures: Prospective Observational Study.

Jan 24, 2022

Postoperative infections after brain surgery are a serious complication potentially worsening the outcome of surgical treatment. Severe intraoperative hyperglycemia (SIH) contributes to both infectiou...

KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer.

Jan 24, 2022

Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence resistance to PTX in EOC. KH domain-c...

Targeted delivery of exosomal miR-484 reprograms tumor vasculature for chemotherapy sensitization.

Jan 24, 2022

The vascular dysfunction of ovarian cancer (OC) contributes to the chemotherapeutic resistance. In this study, we aimed to explore whether exosome-mediated angiogenesis blocking could improve the chem...

Oral Abundance of Actinomyces spp. in Breast Cancer Patients.

Jan 24, 2022

Pathophysiology of medication-related osteonecrosis of the jaw (MRONJ) is still unclear and disease development is associated with adverse reaction of bisphosphonates and denosumab, and Actinomyces sp...

Long-Term Outcomes and Prognostic Factors of Patients with Metastatic Solid Tumors Admitted to the Intensive Care Unit.

Jan 24, 2022

Admission of metastatic cancer patients to the intensive care unit (ICU) poses medical and ethical challenges in the absence of reliable prognostic tools to guide decision-making.We retrospectively an...

Predictors of Medication Initiation and Retention in Treatment for Opioid Use Disorder in Pregnant Women in the United States, 2013–2017

Jan 21, 2022

For a study, researchers described trends and characteristics related to opioid use disorder (OUD) medication administration and treatment retention among pregnant women with OUD. A retrospective, cou...

A Wireless Self-Guided Fatal Heart Rate Monitor's Accuracy, Clinical Utility, and Usability

Jan 21, 2022

For a study, researchers tried to assess the accuracy, clinical value, and usability of a wireless fetal and maternal heartbeat monitor for monitoring fetal heart rate (FHR). A convenience sample of w...

Experiences of pregnant women and healthcare professionals of participating in a digital antenatal CMV education intervention.

Jan 17, 2022

The study aimed to explore the perspectives of participating pregnant women and Health Care Professionals (HCPs) towards receiving and providing cytomegalovirus (CMV) education so that barriers and fa...

Factors associated with poor maternal health care services utilization in Eswatini: A secondary analysis of a nationally representative household survey.

Jan 17, 2022

This study investigated the prevalence and factors associated with poor maternal health care services utilization (MHCSU) i.e., having < 4 antenatal care (ANC) visits, not delivering at a health fa...

Advocating for equitable management of hereditary cancer syndromes.

Jan 17, 2022

The potential for preventive medicine to lead to more equitable health outcomes exists with the inclusion of genetic testing in medicine. Because of the medical implications of genetic testing for he...

Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches.

Jan 17, 2022

Dysregulation of the discoidin domain receptor (DDR1), a collagen-activated receptor tyrosine kinase, has been linked to several human cancer diseases including non-small cell lung carcinoma (NSCLC), ...

The endometriosis daily diary: qualitative research to explore the patient experience of endometriosis and inform the development of a patient-reported outcome (PRO) for endometriosis-related pain.

Jan 17, 2022

Endometriosis is a chronic disorder of the female reproductive system characterized by debilitating symptoms, particularly endometriosis-related pain (ERP). Patient-reported outcome (PRO) measures of ...

An integrated in silico analysis highlighted angiogenesis regulating miRNA-mRNA network in PCOS pathophysiology.

Jan 17, 2022

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinopathy and a leading cause of anovulatory infertility. Angiogenesis is vital for ovarian folliculogenesis. The expression of angiogenesis-as...

Evolution of low HER2 expression between early and advanced-stage breast cancer.

Jan 17, 2022

Low human epidermal growth factor receptor 2 (HER2) expression is emerging as an actionable biomarker for the treatment of breast cancer (BC) with novel anti-HER2 drugs. However, the evolution of this...

Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics.

Jan 17, 2022

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors by suppressing the expression of target genes, some of which are engaged in angiogenic signaling pathways directly or indirectly. Tumor develop...

iSingle Dose Antibiotic Therapy for Urinary Infections during Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Jan 10, 2022

During pregnancy, urinary infections are an important cause of maternofetal morbimortality and may lead to several complications.Verify whether the use of antibiotic therapy in a single dose when comp...

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