Examining the Risk of VTE in Ovarian Cancer
Published research has shown that women with ovarian cancer have among the highest rates of venous...
Ovarian Cancer
Prescribed Medical Cannabis in Women With Gynecologic Malignancies
Although cannabis remains illegal in many parts of the United States, 33 states have approved...
Characterizing the Treatment of Women With Early Stage Leiomyosarcoma
Leiomyosarcoma (LMS) is a rare gynecologic malignancy, but it contributes to a significant...
Comparing Treatments for Early-Stage Endometrial Cancer With Lymphovascular Space Invasion
Research indicates that women with early-stage endometrial cancer who have lymphovascular space...
Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study.
ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the fatty acid synthesis. Lipids and fatty acids were found to be accumulated in different...
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin-dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OVCA). Thus, we...
Sentinel lymph node technique in early-stage ovarian cancer: a phase II clinical trial.
Early-stage ovarian cancer might represent an ideal disease scenario for sentinel lymph node application. Nevertheless, the published experience seems to be limited. Our objective was to assess the feasibility and safety...
Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance.
Epithelial ovarian cancer (EOC) is one of the leading causes of death from gynecologic cancers and peritoneal dissemination is the major cause of death in patients with EOC. Although the loss of 4.1N is associated with increased...
Serum lncRNA LOXL1-AS1 is a diagnostic and prognostic marker for epithelial ovarian cancer.
The objective of our research was to examine the levels of circulating LOXL1-AS1 in EOC patients and to analyze its diagnostic and prognostic value.The levels of LOXL1-AS1 in 185 EOC patients and 43 healthy volunteers were...
Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer.
Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatment are currently lacking.The...
Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study.
Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates in OC because of its heterogeneity....
Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents.
The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes 1-6 showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values...
