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Pain General

Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.

May 06, 2021

To compare the analgesic effect of morphine combined with maropitant and/or dexmedetomidine to morphine alone given at a higher dose, and to evaluate the pharmacokinetics of the drug combinations, in ...

Predictive Performance of Oximetry to Detect Sleep Apnea in Patients Taking Opioids.

May 06, 2021

Long-term use of opioids for treatment of chronic pain is associated with significant risks including worsening unrecognized or untreated sleep apnea that may increase morbidity and mortality. Overnig...

Fentanyl-related substance scheduling as an effective drug control strategy.

May 06, 2021

Fentanyl is now the primary driver of the current opioid crisis. Fentanyl and its analogues are subject to the Controlled Substances Act of 1970, the Controlled Substances Analogue Enforcement Act of ...

Own experience in the diagnosis and treatment of elongated styloid process syndrome.

May 06, 2021

<b>Introduction:</b> The aim of the study was to present selected cases with Eagle's syndrome diagnosed and treated at the Department of Otolaryngology, Laryngological Oncology, Audiology ...

The impact of Coronavirus disease 2019 (COVID-19) pandemic on migraine disorder.

May 06, 2021

To evaluate the impact of the Coronavirus disease of 2019 (COVID-19) pandemic on patients with migraine.Self-reported data from a migraine tracking smartphone application, Migraine Buddy, were used. D...

Galcanezumab Provides Consistent Efficacy Throughout the Dosing Interval Among Patients with Episodic and Chronic Migraine: A Post Hoc Analysis.

May 06, 2021

The consistency of the treatment effect of galcanezumab throughout the dosing interval is examined in patients with episodic and chronic migraine.This study was a post hoc analysis of clinical trial d...

Osteopathic medicine for fibromyalgia: a sham-controlled randomized clinical trial.

May 06, 2021

Patients with fibromyalgia (FM) frequently resort to osteopathic or chiropractic treatment, despite very weak supporting evidence. We aimed to assess the efficacy of osteopathic manipulation in FM in ...

Interoceptive Sensibility, Alexithymia, and Emotion Regulation in Individuals Suffering from Fibromyalgia.

May 06, 2021

People suffering from fibromyalgia syndrome report various difficulties in emotional processing, possibly resulting from changes in bodily perception (interoception). In our study, we investigated the...

Bioactive lipid mediators in the initiation and resolution of inflammation after spinal cord injury.

May 06, 2021

Neuroinflammation is a prominent feature of the response to CNS trauma. It is also an important hallmark of various neurodegenerative diseases in which inflammation contributes to the progression of p...

Sagittal reduction of spinal deformity: superior versus lateral screw-rod connection.

May 06, 2021

Introduction Spinal malalignment can greatly impact a patient's quality of life. Various sagittal parameters are used as realignment goals; however, about 50% of patients end up being under-corrected ...

Association between interleukin-1 alpha rs1800587 polymorphism and rheumatoid arthritis: A meta-analysis.

May 06, 2021

No consistent results have been reached on the relationship of interleukin-1 (IL-1) rs1800587 polymorphism with the susceptibility to rheumatoid arthritis (RA) so far. Therefore, the current meta-anal...

The efficacy and safety of silver needle in the treatment of rheumatoid arthritis: A protocol of randomized controlled trial.

May 06, 2021

Rheumatoid arthritis is a kind of chronic crippling disease, the condition is complex, the course of the disease is repeated, seriously affecting the quality of life of patients. Adverse reactions and...

Rheumatoid Arthritis and Associated-Interstitial Lung Disease: Mortality Rates and Trends.

May 06, 2021

The burden of rheumatoid arthritis (RA) and RA-associated interstitial lung disease (RA-ILD) in recent years has not been well characterized.In this study, we sought to describe RA and RA-ILD-related ...

β2 adrenergic receptor mediates noradrenergic action to induce CREB phosphorylation in satellite glial cells of dorsal root ganglia to regulate visceral hypersensitivity.

May 06, 2021

Sympathoneuronal outflow into dorsal root ganglia (DRG) is suggested to be involved in sympathetically maintained chronic pain, which is mediated by norepinephrine (NE) action on DRG cells. The presen...

A thermal nociceptive patch in S2 cortex of nonhuman primates: a combined fMRI and electrophysiology study.

May 06, 2021

Human fMRI and behavioral studies have established the roles of cortical areas along the sylvian fissure in sensing subjective pain. Yet, little is known about how sensory aspects of painful informati...

Trans-Nasal High-Flow Dry Gas Reduces Migraine Pain

May 03, 2021

“Migraine headaches affect more than 12% of the United States population, mostly females, and result in significant impairment of quality of life and loss of productivity,” explains Rushil Shah, M...

RA and depression.

May 03, 2021

Depression constitutes the most frequent comorbid condition associated with rheumatoid arthritis (RA), with prevalence rates ranging from 14% to 48%. This wide range can be explain by several factors ...

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021.

May 03, 2021

Cerebral venous sinus thrombosis (CVST) with thrombocytopenia, a rare and serious condition, has been described in Europe following receipt of the ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca), which u...

Update on pain in arthritis.

Apr 29, 2021

Osteoarthritis is a degenerative joint disease that features pain as a hallmark symptom. This review summarises progress and obstacles in our understanding of pain mechanisms in arthritis.Pain phenoty...

Association of chronic pain with comorbidities and health care utilization: a retrospective cohort study using health administrative data.

Apr 29, 2021

Health administrative data provide a potentially robust information source regarding the substantial burden chronic pain exerts on individuals and the health care system. This study aimed to use healt...

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