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Pain General

Comparison of Functional and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion and Posterolateral Fusion Techniques in the Treatment of Lumbar Spinal Stenosis.

May 20, 2021

This study aimed to compare posterolateral fusion with transforaminal lumbar interbody fusion (PLF + TLIF) and PLF only in terms of revision surgery rates and complications, as well as functional and ...

"Precision Medicine in Autoimmune Diseases: Fact or Fiction".

May 20, 2021

Much is said about precision medicine, but its real significance and the possibility of making it a real possibility is far from certain. Several studies in each of the autoimmune diseases have provid...

A systematic review and network meta-analysis on the safety of early interventional treatments in rheumatoid arthritis.

May 20, 2021

To evaluate the safety of treatment strategies in patients with early rheumatoid arthritis (RA).Systematic searches of MEDLINE, EMBASE and PubMed were conducted up to September 2020. Double-blind rand...

Does Tocilizumab have a Role in Dermatology? A Review of Clinical Applications, its Adverse Side Effects and Practical Considerations.

May 20, 2021

Tocilizumab is a humanised monoclonal antibody to the interleukin-6 (IL-6) receptor which was first approved for use in refractory rheumatoid arthritis almost a decade ago. Since then, its use has exp...

Longitudinal, bidirectional relationships of insomnia symptoms and musculoskeletal pain across adolescence: the mediating role of mood.

May 20, 2021

Previous studies have established a bidirectional relationship between sleep and pain, and mood has been proposed as a mediator of this relationship. There are only a limited number of longitudinal st...

Risk factors for persistent pain after breast and thoracic surgeries: a systematic literature review and meta-analysis.

May 20, 2021

Persistent postsurgical pain (PPSP) is common after breast and thoracic surgeries. Understanding which risk factors consistently contribute to PPSP will allow clinicians to apply preventive strategies...

Relationship between gait complexity and pain attention in chronic low back pain.

May 20, 2021

Clinical models of chronic low back pain (cLBP) highlight the role of excessive attention to pain and kinesiophobia on the origin of disability. At the motor control level, various mechanisms are invo...

The Link Between Synovitis & Symptomatic Knee Osteoarthritis

May 19, 2021

“With an absence of effective, licensed disease-modifying treatments for OA, attention has turned to identifying clinically important targets for clinical trials,” explains Thomas Perry, PhD. “S...

Inverse OARSI-OMERACT Criteria Valid Gauge of Worsening KOA

May 17, 2021

“To address the growing focus on using patient-reported outcomes (PRO) and individual-specific outcomes when assessing osteoarthritis (OA), a strategy that defines clinically meaningful improvement ...

Efficacy and safety of jakinibs in rheumatoid arthritis: a systematic review and meta-analysis.

May 17, 2021

To assess the efficacy and safety of jakinibs for the treatment of active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biologic disease...

Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain.

May 17, 2021

Dorsal root ganglion field stimulation (GFS) relieves evoked and spontaneous neuropathic pain by use-dependent blockade of impulse trains through the sensory neuron T-junction, which becomes complete ...

Prevalence of chronic pain among adults in the United States.

May 17, 2021

Chronic pain is associated with reduced quality of life, increased medical expenditures, and significant economic costs. Chronic pain is among the most common chronic conditions in the United States, ...

Shedding light on pain for the clinic: a comprehensive review of using functional near-infrared spectroscopy to monitor its process in the brain.

May 17, 2021

Pain is a complex experience that involves sensation, emotion, and cognition. The subjectivity of the traditional pain measurement tools has expedited the interest in developing neuroimaging technique...

Knee Osteoarthritis: Personalizing Shared Decision Making

May 13, 2021

Shared decision making (SDM) in knee osteoarthritis (OA) is essential to optimizing patient-centered care and involves clinicians and patients collaborating to make decisions using the best available ...

Input-output slope curve estimation in neural stimulation based on optimal sampling principles.

May 13, 2021

This paper discusses some of the practical limitations and issues, which exist for the input--output (IO) slope curve estimation (SCE) in neural, brain and spinal, stimulation techniques. The drawback...

Imbalance in Axial-plane Rotator Cuff Fatty Infiltration in Posteriorly Worn Glenoids in Primary Glenohumeral Osteoarthritis: An MRI-based Study.

May 13, 2021

Fatty infiltration of the rotator cuff evaluated with CT has been associated with asymmetric glenoid wear and humeral head subluxation in patients with glenohumeral arthritis. The relationship between...

Achieving reliable pain change scores for individuals in postoperative phase: carefully choose sampling density, test length, and administration mode.

May 13, 2021

Despite tremendous efforts to increase the reliability of pain measures and other self-report instruments, improving or even evaluating the reliability of change scores has been largely neglected. In ...

Evaluation of four field portable devices for the rapid detection of mitragynine in suspected kratom products.

May 10, 2021

The development of a method for the rapid screening of food and drug products for constituents such as mitragynine, the most abundant alkaloid found in Mitragyna speciosa (kratom) plant leaves, has be...

Genome-wide association study identifies the virulence-associated marker in Streptococcus suis serotype 2.

May 10, 2021

Streptococcus suis (S. suis) has been reported to be a highly invasive pathogen in swine, which causes severe infections like meningitis, arthritis and septicemia, and also a zoonotic agent for humans...

What do patients value learning about pain? A mixed-methods survey on the relevance of target concepts after pain science education.

May 10, 2021

Pain education is a popular treatment approach for persistent pain that involves learning a variety of concepts about pain (ie, target concepts), which is thought to be an important part of recovery. ...

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