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Asthma

The effects of genotype × phenotype interactions on silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells.

Jun 25, 2020

Silver nanoparticles (AgNP) are used in multiple applications but primarily in the manufacturing of antimicrobial products. Previous studies have identified AgNP toxicity in airway epithelial cells, b...

Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts.

Jun 22, 2020

Bronchial asthma is believed to be provoked by the interaction between airway inflammation and remodeling. Airway remodeling is a complex and poorly-understood process, and controlling it appears key ...

Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Due to E-cigarette Use.

Jun 18, 2020

Whilst nearly 3,000 e-cigarette-related hospitalizations have been reported in North America, the long-term outcomes in these patients have not been described. We followed an 18-year-old male who surv...

New Perspectives on Difficult Asthma; Sex and Age of Asthma-Onset Based Phenotypes.

Jun 18, 2020

Asthma is a diverse condition that differs with age and sex. However, it remains unclear how sex, age of asthma-onset, and/or their interaction, influence clinical expression of more problematic adult...

Cumulative incidence of post-infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis.

Jun 15, 2020

Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma/wheezing (AW) among term and pre-term infants. We describe the cumulative incidence of AW among hospitaliz...

Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma.

Jun 15, 2020

The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation...

A Comprehensive Evaluation of Mepolizumab Effectiveness in a Real-Life Setting.

Jun 11, 2020

Interleukin-5 (IL-5) is the principal cytokine regulating eosinophil growth, differentiation, activation, and expression. It is a specific target of mepolizumab, an anti-IL-5 monoclonal antibody used ...

Current approaches to handling rescue medication in asthma and eczema randomised controlled trials are inadequate: a systematic review.

Jun 08, 2020

To examine how rescue medication is defined, reported and accounted for in randomised controlled trials (RCTs) in eczema and asthma populations.A systematic review of phase II/III RCTs evaluating mono...

Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease.

Jun 08, 2020

Epidemiological studies found that increases in the concentrations of airborne particulate matter (PM) smaller than 10 microns diameter (PM) in the ambient air due to desert dust outbreaks contribute ...

Pulmonary Disease Burden in Hispanic and Non-Hispanic Children with Sickle Cell Disease.

Jun 04, 2020

Pulmonary complications are the leading cause of morbidity and mortality in sickle cell disease (SCD) patients. Research in SCD has predominantly been conducted on African-Americans, and the disease b...

REGRESSION OF THE NAVIER-STOKES EQUATION SOLUTIONS FOR PULMONARY AIRWAY FLOW USING NEURAL NETWORKS.

May 28, 2020

Computerized fluid dynamics models of particle deposition in the human airways are used to characterize deposition patterns that enable the study of lung diseases like asthma and chronic obstructive p...

Sterilization plan of the used metered dose inhalers (MDI) to avoid wastage amid COVID-19 pandemic drug shortage.

May 28, 2020

Background Coronavirus is causing a shortage of critical inhalers needed by patients with Asthma and respiratory illness. Patients with Asthma are at higher risk if they tract the novel Coronavirus. A...

CME: Obstructive Lung Disease: Comparing Inhaler Education Approaches

May 26, 2020

This course discusses a study that explored if the virtual teach-to-goal (TTG) intervention was as effective as in-person TTG education for improving inhaler technique among patients hospitalized with...

Asthma-Related ED Visits in Children With Depression & Anxiety

Mar 18, 2020

Research indicates that adults with asthma as well as depression, anxiety, or both demonstrate higher asthma-related healthcare use, including emergency department (ED) visits. Naomi S. Bardach, MD, ...

Office Spirometry: Indications and Interpretation.

Mar 13, 2020

High-quality, office-based spirometry provides diagnostic information as useful and reliable as testing performed in a pulmonary function laboratory. Spirometry may be used to monitor progression of l...

Does the Hospital Admission of Patients with Respiratory Disease Increase in Izmir When the PM10 Level is High?

Mar 13, 2020

Air pollution is caused by exhaust emissions from motor vehicles, fuel consumption for heating of residences, and especially emissions from industrial facilities around the world. The exposure to outd...

Anti-IL-5 Biologicals Targeting Severe Late Onset Eosinophilic Asthma.

Mar 13, 2020

Improved knowledge about the pathogenesis of asthma has facilitated the development of novel drugs and provided hope for patients with severe asthma. After the short- and long-term success of omalizum...

EoTHINophils: Eosinophils as key players in adipose tissue homeostasis.

Mar 13, 2020

Eosinophils are granular cells of the innate immune system that are found in almost all vertebrates and some invertebrates. Knowledge of their wide-ranging roles in health and disease has largely been...

RAPP-children: a new tool for assessing quality of life in patients with asthma and rhinitis.

Mar 13, 2020

RhinAsthma Patient Perspective (RAPP) is a short, validated questionnaire for assessing health-related quality of life (HRQoL) in adult patients with comorbid asthma and rhinitis, while a paediatric v...

Implementing Pediatric Inpatient Asthma Pathways.

Mar 12, 2020

are succinct, operational versions of evidence-based guidelines. Studies have demonstrated pathways improve quality of care for children hospitalized with asthma, but we have limited information on o...

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