Cytokine Storm: The Sudden Crash in Patients with COVID-19
It’s jarring every time. The sudden crash in patients with COVID-19 All over the world,...
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Flu
New guidelines on caring for ICU patients with COVID-19
International panel does quick turnaround McMaster University Hamilton, ON (April 1, 2020) –...
Read MoreSubtype diversity of influenza A virus in North American waterfowl: a multi-decade study.
The discovery in 1976 of waterfowl as the primary reservoir of influenza A viruses (IAV) has since spurred decades of waterfowl surveillance efforts by researchers dedicated to understanding the ecology of IAV and its subsequent...
Read MoreInfluenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms.
Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein...
Read MoreHuman respiratory syncytial virus and influenza seasonality patterns-Early findings from the WHO global respiratory syncytial virus surveillance.
Human respiratory syncytial virus (RSV) causes illnesses among all age groups and presents a burden to healthcare services. To better understand the epidemiology and seasonality of RSV in different geographical areas, the World...
Read MoreAdeno-associated virus-vectored influenza vaccine elicits neutralizing and Fcγ receptor-activating antibodies.
The current seasonal inactivated influenza vaccine protects only against a narrow range of virus strains as it triggers a dominant antibody response toward the hypervariable hemagglutinin (HA) head region. The discovery of rare...
Read MoreMulticenter evaluation of the QIAstat Respiratory Panel-A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections.
Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and...
Read MoreEnvironmental complex exposure and the risk of influenza-like illness among housewives: A case study in Shanxi Province, China.
The association between environmental pollution and risk of influenza-like illness (ILI) among general population has been reported. However, the relationships between the individual pollutants and ILI risk are still under...
Read MoreThe humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections.
We have engineered a Human Immune System (HIS)-reconstituted mouse strain (DRAGA mouse: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD) in which the murine immune system has been replaced by a long-term, functional HIS via infusion...
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