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ADHD/ADD

What Is the Return on Investment of Caring for Complex High-need, High-cost Patients?

Sep 13, 2021

Randomized controlled trials to improve care for complex, high-need, high-cost patients have not consistently demonstrated a relative decrease in acute care utilization or cost savings. However, the V...

A scoping review of the determinants of foetal alcohol spectrum disorder in South Africa: an intersectional perspective.

Sep 13, 2021

Foetal alcohol spectrum disorder (FASD) affects babies born to mothers who consume alcohol while pregnant. South Africa has the highest prevalence of FASD in the world. We review the social determinan...

Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls.

Aug 19, 2021

The dopamine D4 receptor gene (DRD4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). Recent studies have linked DRD4 to functional connectivity am...

Add-on cannabidiol in patients with Dravet syndrome: Results of a long-term open-label extension trial.

Aug 19, 2021

Add-on cannabidiol (CBD) reduced seizures associated with Dravet syndrome (DS) in two randomized, double-blind, placebo-controlled trials: GWPCARE1 Part B (NCT02091375) and GWPCARE2 (NCT02224703). Pa...

Customizable Natural Language Processing Biomarker Extraction Tool.

Aug 19, 2021

Natural language processing (NLP) in pathology reports to extract biomarker information is an ongoing area of research. MetaMap is a natural language processing tool developed and funded by the Nation...

A technology of a different sort: microraft arrays.

Aug 05, 2021

A common procedure performed throughout biomedical research is the selection and isolation of biological entities such as organelles, cells and organoids from a mixed population. In this review, we de...

Influence of sample preparation optimization on the accuracy of dose assessment of an automatic non-fluorescent MN scoring system.

Aug 05, 2021

Automatizing the scoring of the cytokinesis-blocked micronucleus assay spares a lot of valuable time. The dose-effect relationship can be applied reliably for dose estimation, if the quality of the s...

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies.

Aug 05, 2021

The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming th...

"Why can't you sit still?"The effect of daily physical activity on childhood inattention/hyperactivity and the educational gender gap.

Jul 26, 2021

Despite the compelling evidence of the long-run consequences of childhood inattention/hyperactivity and harmful side effects of stimulant medication, relatively little is known about accessible non-ph...

The Effects of Combined Physical and Cognitive Training on Inhibitory Control: A Systematic Review and Meta-Analysis.

Jul 15, 2021

While strong inhibitory control is critical for health and wellbeing, there are no broadly applicable effective behavioural interventions that enhance it. This meta-analysis examined the neurocognitiv...

Phylogeography of an endemic California silk moth genus suggests the importance of an unheralded central California province in generating regional endemic biodiversity.

Jul 15, 2021

The California Floristic province is a biodiversity hotspot. Understanding the phylogeographic patterns that exist in this diverse region is essential to understanding its evolution and for guiding co...

Impact of L2 automated systems on hazard anticipation and mitigation behavior of young drivers with varying levels of Attention Deficit Hyperactivity Disorder symptomatology.

Jul 15, 2021

Level 2 (L2) driving automation systems that maintain latitudinal and longitudinal control of the vehicle decrease mental workload and result in drivers failing to monitor and respond to potential roa...

Innovative preclinic triage system to guide Australians to the right mental health care first time.

Jun 24, 2021

This paper presents a case study of an innovative direct-to-consumer preclinic triage system designed to reduce predicted peak demand for Australian mental health services as a result of COVID-19 and ...

Effects of a Video-Based mHealth Program for Homebound Older Adults: Study Protocol for a Pilot Randomized Controlled Trial.

Jun 24, 2021

Although homebound older adults are among the highest users of hospital services, the existing health and social services that are provided to them in the community are limited and fragmented. This st...

A Novel L1 Linker Mutation in DES Resulted in Total Absence of Protein.

Jun 10, 2021

Desminopathies (MIM*601419) are clinically heterogeneous, manifesting with myopathy and/or cardiomyopathy and with intra-sarcoplasmic desmin-positive deposits. They have either an autosomal dominant (...

Cost-Utility Analysis of Dapagliflozin as an Add-On to Standard Treatment for Patients with Type 2 Diabetes and High Risk of Cardiovascular Disease in Thailand.

Jun 10, 2021

Diabetes treatment has incurred financial burden. We examined the cost-utility of adding dapagliflozin to the standard treatment for treating type 2 diabetes (T2DM) with cardiovascular risk in a Thai...

Relationship between enteral nutrition and serum levels of inflammatory factors and cardiac function in elderly patients with heart failure: A protocol for systematic review and meta-analysis.

Jun 10, 2021

: Published studies investigating enteral nutrition's effect on serum inflammatory factors and the cardiac function of malnourished elderly patients with heart failure (HF) are of poor quality, with s...

Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD-dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.

Jun 03, 2021

NAD-dependent DNA ligase (LigA) is the principal bacterial ligase and catalyses a multistep ligation reaction. The adenylation (AdD) domain at the N-terminus consists of subdomains 1a and 1b, where su...

ADHD, stimulant medication use, and the risk of fracture: a systematic review and meta-analysis.

Jun 03, 2021

We performed a meta-analysis to quantify the relationships among a diagnosis of attention-deficit/hyperactivity disorder (ADHD), the use of stimulant medication, and the risk of fracture. There was a ...

Benefits and challenges of mobility and medical alert service dogs for caregivers of service dog recipients.

Jun 03, 2021

Mobility and medical alert service dogs are an assistive technology for individuals with disabilities or chronic conditions. Informal caregivers of individuals with disabilities are subject to physica...